We present a sensing system operating at millimetre (mm) waves in transmission mode that can measure glucose level changes based on the complex permittivity changes across the signal path. The permittivity of a sample can change significantly as the concentration of one of its substances varies: for example, blood permittivity depends on the blood glucose levels. The proposed sensing system uses two facing microstrip patch antennas operating at 60 GHz, which are placed across interrogated samples. The measured transmission coefficient depends on the permittivity change along the signal path, which can be correlated to the change in concentration of a substance. Along with theoretical estimations, we experimentally demonstrate the sensing performance of the system using controlled laboratory samples, such as water-based glucose-loaded liquid samples. We also present results of successful glucose spike detection in humans during an in-vivo Intravenous Glucose Tolerance Test (IVGTT). The system could eventually be developed into a non-invasive glucose monitor for continuous monitoring of glucose levels for people living with diabetes, as it can detect as small as 1.33 mmol/l (0.025 wt%) glucose concentrations in the controlled water-based samples satisfactorily, which is well below the typical human glucose levels of 4 mmol/l.

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We present an approach to enhance microwave brain imaging with an innovative metamaterial (MM) planar design based on a cross-shaped split-ring resonator (SRR-CS). The proposed metasurface is incorporated in different setups, and its interaction with EM waves is studied both experimentally and by using CST Microwave Studio® and is compared to a “no MM” case scenario. We show that the MM can enhance the penetration of the transmitted signals into the human head when placed in contact with skin tissue, acting as an impedance-matching layer. In addition, we show that the MM can improve the transceivers’ ability to detect useful “weak” signals when incorporated in a headband scanner for brain imaging by increasing the signal difference from a blood-like dielectric target introduced into the brain volume. Our results suggest that the proposed MM film can be a powerful hardware advance towards the development of scanners for brain haemorrhage detection and monitoring.