In the study, wave propagation along aorta is studied for different normal and pathological conditions in distal arteries. The mathematical model is based on the axisymmetric incompressible Navier-Stokes equations for blood and momentum equations for an incompressible viscoelastic arterial wall. The solution has been found as a superposition of forward and backward running waves. The blood pressure and flow curves measured by ultrasound in larger systemic arteries of ten healthy volunteers have been used for identification of the model parameters. It is shown that individual geometry plays an essential role in the location of positive and negative wave reflection sites along the aorta and, thus, in the pressure and flow patterns as well as blood distribution into the side branches. The model is validated by comparative study with the same dependencies computed previously on a 55-tube model as well as on the measurement data. The model can be used for determination of the individual parameters for patient-specific cardiovascular models and further in silico modeling of the outcomes of surgical and therapeutic procedures.
Biological tissues and their artificial substitutes are composed by different fibers and possess complex viscoelastic properties. Here the most popular 3-element and 5-element rheological models of human soft tissues as viscoelastic bodies are considered accounting for the time delay between the load and mechanical respond of the material.The obtained data compared to the experimental curves got on the vessel wall and heart tissues.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.