and GaV4S8. -The title compounds are characterized by self-consistent electronic structure calculations using DFT. GeV4S8 exhibits the magnetic space group Pbmn21 with Z = 4 at 4 K as revealed by powder neutron diffraction. Both compounds undergo structural distortions from cubic to rhombohedral (GaV4S8) or orthorhombic (GeV4S8) symmetry at low temperatures. The Ga-compound is ferromagnetic below T C = 10 K, whereas the Ge-compound shows antiferromagnetic order with TN = 13 K. The interplay between the electronic, lattice, and spin degrees of freedom of the V4 cluster units and the physical and structural properties of the highly correlated title compounds is discussed. -(MUELLER, H.; KOCKELMANN, W.; JOHRENDT*, D.; Chem.
This manuscript discusses the recent report "Cognate restriction of transposition by piggyBac-like proteins" in Nucleic Acids Research by Beckermann et al and related recent publications about the inability to detect DNA transposition activity of human domesticated DNA transposase PGBD5. Measuring DNA transposition activity of transposases in human cells, where these enzymes can act on endogenous genomic substrates and induce DNA damage, is complicated by these and other cellular responses. Possible reasons for the discordant findings of Beckermann et al with prior independent reports of PGBD5 DNA transposition by Helou et al and Henssen et al and specific details of experimental methods in human cells are presented. In particular, by using independent experiments that reproduce PGBD5-mediated genomic integration, we demonstrate how supraphysiologic and ectopic overexpression of PGBD5 can cause DNA damage and cell death, and artifactual loss of apparent activity in clonogenic transposition reporter assays. While PGBD5 can support apparent DNA transposition, its cellular activity predominantly involves double-strand DNA breaks, deletions and other DNA rearrangements. We discuss the implications of this phenomenon for the interpretation of experimental assays and activities of domesticated DNA transposases.
The Stannide LiRh 3 Sn 5 -Synthesis, Structure, and Chemical Bonding. -The title compound is synthesized from a stoichiometric mixture of the elements (670 K, 14 d). LiRh3Sn5 crystallizes in the space group Pbcm with Z = 4 (single crystal XRD). The structure consists of a complex three-dimensional [Rh3Sn5] network, in which the Li atoms fill channels. DFT band structure calculations indicate strong Rh-Sn bonds and significant Rh-Rh bonding within the Rh 3 Sn 5 network, which is additionally stabilized by weak but frequent Sn-Sn interaction. -(SREERAJ, P.; JOHRENDT, D.; MUELLER, H.; HOFFMANN, R.-D.; WU, Z.; POETTGEN*, R.; Z. Naturforsch., B: Chem. Sci. 60 (2005) 9, 933-939; Inst. Anorg. Anal. Chem.,
Der heterometallische geschlossene tetraedrische Cluster (I) läßt sich bei 20°C mit 2 bar CO unter Spaltung einer Mn‐Fe‐Bindung zum halbgeöffneten Cluster (IIa) umwandeln.
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