It was purposed to evaluate the biological potential of ethanol and isopropanol crude
extracts of ripe Physalis peruviana fruits. Cytotoxic and
immunomodulatory effects of the expression of interleukin-6, interleukin-8, and monocyte
chemoattractant protein-1 (MCP-1) were evaluated on human cervical cancer (HeLa) and
murine fibroblast (L929) cells. The composition was evaluated by high-performance liquid
chromatography diode-array detection and high-performance liquid chromatography
ultraviolet/visible detection. The presence of ursolic acid and rosmarinic acid was found
in both solvents. However, gallic acid, quercetin, and epicatechin were higher in
isopropanol extracts (P < .05). The results indicated a relationship
among the total polyphenol content, antioxidant activity, and cytotoxic activity that was
dependent on the solvent used. Isopropanol extracts presented a half-maximal inhibition
concentration value (IC50) of 60.48 ± 3.8 μg/mL for HeLa cells and 66.62 ± 2.67
μg/mL for L929 fibroblasts. The extracts reduced the release of interleukin-6,
interleukin-8, and MCP-1 in a dose-dependent manner. Extracts showed anticancer and
immunomodulatory potential for new complementary pharmaceutical products development.
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