This review presents the recent progress in the synthesis of azaspiro[4.4]nonane focussing on key steps. The syntheses of both racemic and non-racemic compounds are described. 1 Introduction 2 Formation of a Cyclopentane Ring onto a Pre-existing Pyrrolidine Derivative 3 Formation of a Pyrrolidine Ring onto a Pre-existing Cyclopentane Derivative 4 Conclusions
Domino effect: The skeleton of erythrina and B‐homoerythrina alkaloids can be constructed in an efficient manner from readily available substrates (see Scheme) by a three‐step domino reaction. These natural products constitute an interesting class of compounds because of their extensive biological activity.
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