BackgroundIn radiology, a vast amount of diverse data is generated, and unstructured reporting is standard. Hence, much useful information is trapped in free-text form, and often lost in translation and transmission. One relevant source of free-text data consists of reports covering the assessment of changes in tumor burden, which are needed for the evaluation of cancer treatment success. Any change of lesion size is a critical factor in follow-up examinations. It is difficult to retrieve specific information from unstructured reports and to compare them over time. Therefore, a prototype was implemented that demonstrates the structured representation of findings, allowing selective review in consecutive examinations and thus more efficient comparison over time.MethodsWe developed a semantic Model for Clinical Information (MCI) based on existing ontologies from the Open Biological and Biomedical Ontologies (OBO) library. MCI is used for the integrated representation of measured image findings and medical knowledge about the normal size of anatomical entities. An integrated view of the radiology findings is realized by a prototype implementation of a ReportViewer. Further, RECIST (Response Evaluation Criteria In Solid Tumors) guidelines are implemented by SPARQL queries on MCI. The evaluation is based on two data sets of German radiology reports: An oncologic data set consisting of 2584 reports on 377 lymphoma patients and a mixed data set consisting of 6007 reports on diverse medical and surgical patients. All measurement findings were automatically classified as abnormal/normal using formalized medical background knowledge, i.e., knowledge that has been encoded into an ontology. A radiologist evaluated 813 classifications as correct or incorrect. All unclassified findings were evaluated as incorrect.ResultsThe proposed approach allows the automatic classification of findings with an accuracy of 96.4 % for oncologic reports and 92.9 % for mixed reports. The ReportViewer permits efficient comparison of measured findings from consecutive examinations. The implementation of RECIST guidelines with SPARQL enhances the quality of the selection and comparison of target lesions as well as the corresponding treatment response evaluation.ConclusionsThe developed MCI enables an accurate integrated representation of reported measurements and medical knowledge. Thus, measurements can be automatically classified and integrated in different decision processes. The structured representation is suitable for improved integration of clinical findings during decision-making. The proposed ReportViewer provides a longitudinal overview of the measurements.
We study structural properties of graphs with bounded clique number and high minimum degree. In particular, we show that there exists a function L = L(r,ɛ) such that every Kr-free graph G on n vertices with minimum degree at least ((2r–5)/(2r–3)+ɛ)n is homomorphic to a Kr-free graph on at most L vertices. It is known that the required minimum degree condition is approximately best possible for this result. For r = 3 this result was obtained by Łuczak (2006) and, more recently, Goddard and Lyle (2011) deduced the general case from Łuczak’s result. Łuczak’s proof was based on an application of Szemerédi’s regularity lemma and, as a consequence, it only gave rise to a tower-type bound on L(3, ɛ). The proof presented here replaces the application of the regularity lemma by a probabilistic argument, which yields a bound for L(r, ɛ) that is doubly exponential in poly(ɛ).
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