[Epub ahead of print]. 8. Van Gasse AL, Ebo DG, Chiriac AM, et al. The limited value of prolonged drug challenges in nonimmediate amoxicillin (clavulanic acid) hypersensitivity.
None of the patients with negative SPT and ICT results for rhC1INH had allergic symptoms during rhC1INH challenge. The negative predictive value of the combination of SPT and ICT for the outcome of the SC challenge was 100% (95% CI, 84.6%-100%). SC administration of rhC1INH was well tolerated.
To the Editor, Although relatively rare, immediate perioperative hypersensitivity reactions (POH) are important complications of drug administration prior to, during and after surgical and other interventional procedures. Both the incidence of immediate POH and their major culprits are difficult to establish and vary considerably between reports; the incidence may be as high as 1:1250 or almost a tenfold lower. 1Most studies have a yield of positive allergy test results of 50% to 60%, suggestive of an immunoglobulin E (IgE)-mediated reaction.Neuromuscular blocking agents (NMBA) were shown to be the most common cause of immediate POH in various countries including France and Australia, 2 while other countries (USA, UK, Spain, Denmark) identify antibiotics to be the primary culprit. 1,3,4 Other frequently and increasingly identified culprits in POH are dyes, non-steroidal anti-inflammatory drugs (NSAID), induction agents and colloid solutions (reviewed in 1 ). Dyes such as patent blue
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