Paroxysmal cold haemoglobinuria (PCH) accounts for around a third of cases of autoimmune haemolytic anaemia in children. PCH is caused by an autoantibody that fixes complement to red cells at low temperatures and dissociates at warmer temperatures (a biphasic haemolysin), triggering complement-mediated intravascular haemolysis. Named the Donath-Landsteiner (D-L) antibody after its discoverers, it is usually formed in response to infection and demonstrates specificity for the ubiquitous red cell P-antigen. A D-L test can be used to detect the presence of the D-L autoantibody in the patients’ serum. Here we discuss the use of the D-L test in identifying PCH in a 2-year-old boy who presented with haemolytic anaemia. A summary of the key information can be found in the infographic.
patient and parental satisfaction after PPS to ensure the service we provide meets their needs.Abstract G326(P) Table 1 Participant demographics, n=46 Healthcare professional Number PED Nurse 22 PED Doctor 15 Speciality Doctor 9Abstract G326(P) Table 2 Composite Likert scores (0=not at all, 10=very); n=46; mean (standard deviation) Statement Composite scores I can access PPS 6.0 (±2.7)PPS offers a good alternative to general anaesthesia 9.2 (±1.2) PPS is an efficient process 8.5 (±1.6) PPS provides a good service for patients 8.6 (±1.5)PPS has a negative impact on patient flow 4.2 (±2.1)
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