Anthocyanins as secondary metabolites of berry fruit represent a large number of positive health effects. The physiological effect of polyphenols is a function of their chemical nature and bioavailability. Protective action is linked to their antioxidant, antimutagenic and anticancer activity. The aim of the studies was to determine the effect of ethanol and acetone extracts from berries of the fruits of Vaccinium myrtilus L., Sambucus nigra L., and Aronia melanocarpa L. on mitomycin C-induced plasmid DNA damage. We evaluated the protective effect of ethanol and acetone extracts of Vaccinium myrtilus, Sambucus nigra, and Aronia melanocarpa berry fruits in concentrations of 50, 25 and 10 μg.×ml-1 to plasmid DNA damage induced by mitomycin C, the protective effect of anthocyanins consisted in the formation of copigmentic complex. Anthocyanins inhibited the formation and release of peroxide radicals. We found that V. myrtillus ethanol extract (50 μg/ml) showed the best protective effect on plasmid DNA. The antioxidant and antimutagenic effect of anthocyanins is based on the free radical elimination. The effect was evaluated using horizontal agarose electrophoresis.
Evidence indicates that unhealthy eating habits constitute multilevel obstacles threatening health and well-being. Studies suggest that consumer choices have turned irremovably towards Western diets. The Mediterranean diet (MD) is considered one of the most effective in preventing and treating overweight and obesity, yet its results and associations are ambiguous. This explanatory research aims to examine the effect of the MD on anthropometric and biochemical variables in 181 females from an Eastern European country. The sample was divided into three distinct clusters based on age (tricenarian, quadragenarian, and quinquagenarian). Anthropometric and biochemical examinations in the three-month MD program plan failed to provide convincing evidence of the benefits of the MD on selected integrands. However, total body fat (FATP) values between groups showed a significant difference (p ≤ 0.032) between groups A and C (p ≤ 0.029), which can be attributed to the age of the cohort (30–39 vs. 50–60 years). Values in groups A and B (p ≤ 0.001) and C and A (p ≤ 0.001) were significant between the cohorts but did not indicate any changes in visceral fat (VFATL) in the individual groups. The presented findings can have implications for further investigation and the development of more comprehensive instruments, incorporating critical add-on constituents that will be appropriate to monitor, evaluate, and predict body weight management in experimentation.
Evidence indicates that unhealthy eating habits constitute multilevel obstacles threatening our health and well-being—studies suggesting that consumer choices turn irremovably towards Western diets. Mediterranean diets (MD) have been identified as one of the most effective in preventing and treating overweight and obesity. Considering this scientific substantiation in prevention and treatment activity, the purpose of this investigation is to verify this evidence. In our prospective interventional study, we examined the effect of MD on body weight in a female cohort sample. The analyzed group consisted of (n=181) females divided into three distinct groups based on their age (tricenarian, quadragenarian, and quinquagenarian). Anthropometric (weight, BMI, FATP, VFATL, FFM, TBW, and BMR), biochemical examinations (urea, creatinine, uric acid, ALT, AST, GGT, CHOL, HDL-CH, non-HDL, LDL-CH, TAG, GLU, and CRP) and comprehensive, personalized three months MD program was completed on the examined subjects. We didn’t establish convincing evidence of MD on weight reduction and its magnitude of correlation with a positive correspondence on selected determinants in all groups combined. There is a challenge to construct more robust prospective cohort studies that will incorporate add-on critical integrands that will be appropriate to monitor, evaluate and predict weight management in experimenting.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.