Introduction: Anesthetic therapies in neonatal patients with Myelomeningocele and Macrocephaly have important points to keep in mind. Myelomeningocele (MMC) represents the most severe form of spinal dysraphism. Early surgical treatment was associated with a lower rate of complications. Report: Neonatal term patient, suitable for gestational age, with diagnoses of lumbo-sacral myelomeningocele, bilateral bot foot, Macrocephaly and pyelocalic dilatations in both kidneys. Conclusions: Anesthesia of the patient with multiple malformations poses an anesthetic challenge. The neurological deficit can be minimized through careful attention to the preoperative evaluation, good surgical technique, good hemodynamic control and the subsequent control of a multidisciplinary team to be attentive to complications that may present.
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