Purpose: This study was designed to introduce a standardized protocol for examination of congenital insensitivity to pain with anhidrosis patients. And also report the oro-dental manifestations in these patients. Materials and methods: In the current study, Oro-facial clinical and sensory examinations, as well as radiographic examination for ten CIPA patients were performed. Results: The Oro-dental findings were mainly missing teeth and soft tissue injuries. Radiographic examination revealed multiple congenitally missing teeth. Conclusion: A standardized protocol with Oro-facial clinical and sensory examinations, pulp sensitivity tests and radiographic examination should be considered as a primary diagnostic approach in patients with suspected Congenital insensitivity to pain with anhidrosis, instead of the more established but expensive molecular analysis and the invasive Sural nerve biopsy.
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