This work aimed to evaluate the hepatoprotective effect of garlic oil extract and artichoke extract with regarding to clinical, hematobiochemical alteration and oxidative stress status of induced acute hepatopathy in Baladi goats. Fifteen Baladi goats were kept for experimental induction of hepatopathy that treated orally with 0.3 ml /kg of carbon tetrachloride (CCl4) once and divided randomly into 3 groups each of five. Group A was kept as control positive. Group B and Group C were treated by garlic oil extract in dose 0.8mg/kg and artichoke extract in dose 10mg/kg for 15 days for hepatic protection before induction. Clinical and hematobiochemical examination were carried out at 1 st , 3 rd and 7 th day after induction. Clinical examinations of CCl4 treated group at first day showed dullness, inappetence, pale mucous membranes, elevated body temperature and pulse rate and nervous manifestations. While garlic and artichoke extracts treated groups showed less severe clinical signs that began to disappear at 3 rd day after induction. With the Hematobiochemical examination, the induced acute hepatopathy group showed significant (P<0.05) decrease in RBCs, Hb, PCV, GPX and SOD and significant (P<0.05) increase in WBCs, ALT, AST, GGT, total and direct bilirubin, blood urea nitrogen, creatinine and MDA. While garlic and artichoke extracts treated groups showed significant (P<0.05) increase in RBCs, Hb, PCV and antioxidant status with significant (P<0.05) decrease in liver damage indices of treated animals. Therefore, we concluded that garlic oil extract and artichoke extract could be used as hepatoprotective agent in Baladi goats. Baladi goats.
The objective of the present study was to evaluate clinico-biochemical changes occurred in bacterial diarrhea in Egyptian Buffalo calves less than three months old. The study was carried out on 50 buffalo calves in El-Galaa Military farm that located in Ismailia Governorate, 40 diarrheic calves aged 55-75 days with an average body weight (35±2.5) kg were detected and 10 apparently healthy calves were kept as a control group to investigate the clinico-biochemical profiles. E. coli mixed or co-infection of Acinetobacterbaumannii/ Iwoffiiss species with Klebsiella and pseudomonas species were isolated from the diarrheic calves. Diarrheic calves show signs of anorexia, weakness, dullness, staggering movement, weight loss, pale mucous membranes with sunken eyes and dehydration. Analysis of clinical and biochemical profile of the diarrheic calves revealed significant increase in body temperature, respiratory rate, skin fold test, serum potassium, chloride, urea, creatinine, ALT, AST, GGT, triacylglycerols, cortisol, CRP and CPK with significant decrease in pulse rate, serum sodium, glucose and total protein concentrations. It could be concluded that, bacterial diarrhea has a severe negative impact on the clinical and biochemical profile of the affected buffalo calvesBiochemical Buffalo calves Clinical Diarrhea
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