Copper is an important trace element that plays a very important role in the biochemistry of all living organisms and affects enzymes activity as a cofactor or as a fundamental structure of many metalloenzymes as superoxide dismutase, ceruloplasmin, lysyl oxidase, cytochrome oxidase and tyrosinase. Therefore copper is essential for cellular respiration, free radical defence, neurotransmitter function and tissue biosynthesis. Excessive copper accumulation is toxic in all species as it leads to hepatic cirrhosis, hemolytic anemia and degeneration of basal ganglia. The aim of this review is to give a view on the health issue surrounding copper and animal health including many interested points about copper and fetal maternal relationship, the role of copper in the different body system and the effect of its deficiency and toxicity, as well as focusing on the relationship of copper with metalloenzymes, immunity and DNA.