A number of (1H-1,2,3-triazol-1-yl)benzo[d]thiazoles were synthesized utilizing a versatile Cu-catalyzed azide-alkyne click reaction (CuAAC) on tautomeric benzo[4,5]thiazolo[3,2-d]tetrazole (1) and 2-azidobenzo[d]thiazole (2) starting materials. Moreover, one of the resulting products of this investigation, triazolbenzo[d]thiazole 22, was found to possess significant neuroprotective activity in human neuroblastoma (SH-SY5Y) cells.
Triazolbenzo[d]thiazoles: Efficient Synthesis and Biological Evaluation as Neuroprotective Agents. -Two series of title compounds of type (III) and (VII) are prepared utilizing Cu-catalyzed azide-alkyne click reactions. One of the triazolylbenzothiazoles, i.e. compound (VIIc) possesses significant neuroprotective activity. -(AVILA, B.; ROTH, A.; STREETS, H.; DWYER, D. S.; KURTH*, M. J.; Bioorg. Med. Chem. Lett. 22 (2012) 18, 5976-5978, http://dx.doi.org/10.1016/j.bmcl.2012.07.022 ; Dep. Chem., Univ. Calif., Davis, CA 95616, USA; Eng.) -M. Bohle 04-086
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