Abstract. The aim of the experiment was to study the histological reaction of orthodontic force on the periodontal tissues regenerated by nano biphasic calcium phosphate (NBCP) bioceramics in beagle dogs. Two third incisors were randomly selected and operated as experimental group. The contralateral third incisors of the same jaw were done nothing as control. Alveolar bone defects were surgically created at the labial aspects of the third incisors in two beagle dogs. After root conditioning with ethylenediaminetetraacetate (EDTA), NBCP was filled in the defects. At 24 weeks after implantation the third incisors were moved labially with the adjacent canines for anchorage. Four weeks later dogs were killed. Specimens were processed and stained with hematoxylin and eosin (HE). The results revealed that there was no significant difference in the histological reaction induced by orthodontic tooth movement between the two groups.
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