Background:The role of GOLPH3 in mammalian glycosylation is not well studied. Results: GOLPH3 binds to and controls the Golgi localization of POMGnT1. Conclusion: GOLPH3 regulates the glycosylation of ␣-dystroglycan by anchoring POMGnT1 at the Golgi. Significance: The result provides a further understanding of the role of GOLPH3 in mediating the Golgi localization of glycosyltransferases in mammalian cells.
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