In this study, four emitters of blue light are synthesized by selecting pyrene with its high photoluminescence quantum yield (PLQY) as the core group and variants of the electron-donating diphenylamine (DPA) as side groups. The four compounds have different numbers, sizes, and substitution positions of alkyl groups on the DPA. Each of the four compounds when doped in OLED devices shows a high current efficiency (CE) of over 7 cd A and a high external quantum efficiency (EQE) of over 7.5%. In addition, the compounds yield electroluminescence (EL) spectra showing peaks with narrow full width at half-maximum (fwhm) values of 37-40 nm and hence indicative of high color purity. Moreover, one compound N1,N6-bis(5-( tert-butyl)-2-methylphenyl)-N1,N6-bis(2,4-dimethylphenyl)pyrene-1,6-diamine (3Me-1Bu-TPPDA), shows a very high EQE of 9.25% and a very long lifetime with an LT95 of 471 h.

Introduction: Impairment in DNA damage response and repair (DDR) pathway is known as a predictive biomarker of platinum sensitivity. Recently, DDR alteration is reemphasized as a predictive biomarker of immune checkpoint inhibitor due to its positive correlation to tumor mutation burden (TMB). Methods: Target gene sequencing (381 genes) was conducted from 100 extensive disease (ED) and 66 limited disease (LD) patients with SCLC. Detected mutations were classified as double-strand breaks (DSB) (n ¼ 82): homologous recombination (n ¼ 54), non-homologous end joining (n ¼ 19), and Fanconi anemia (n ¼ 32); or singlestrand breaks (SSB) (n ¼ 31): mismatch repair (n ¼ 19), base excision repair (n ¼ 7), and nucleotide excision repair (n ¼ 6). Results: Compared to patients with an intact DDR pathway (n ¼ 70), a higher TMB was observed in patients with homologous recombination (p < 0.001), non-homologous end joining (p ¼ 0.002), mismatch repair (p < 0.001), DSB (p < 0.001), and SSB (p < 0.001). Survival analyses based on TMB level showed no predictive or prognostic values in ED patients. In LD patients, prolonged progression-free survival (hazard ratio [HR] ¼ 0.497, p ¼ 0.015), and overall survival (HR ¼ 0.383, p ¼ 0.010) to concurrent chemoradiotherapy were observed in those with TMB above median. Individual DDR pathway alteration showed no survival benefit in ED patients receiving platinum-based chemotherapy. In LD patients, those with mutations in the Fanconi anemia gene set had shorter progression-free survival (HR ¼ 2.048, p ¼ 0.036) to initial treatment. Conclusions: DDR pathway alterations, both DSB and SSB, in SCLC have a positive correlation with high TMB. However, it has shown limited value in prediction of platinum efficacy.

We introduced phenyl and naphthyl groups onto various positions of dual cores. Of the synthesized compounds, Na-AP-Na was found to exhibit the highest EL device efficiency of 5.46 cd A−1.