The Mt a antigen is a low-frequency red blood cell (RBC) surface antigen and is an established antigen of the MNSs blood group system. There has been one report of anti-Mt a -induced hemolytic disease of the newborn (HDN) in the literature to date. We describe a family in which three children were affected by neonatal anemia. The clinical and hematologic findings were consistent with HDN, despite repeatedly negative direct antiglobulin tests (DAT) on cord RBCs. Serologic investigations showed that the mother's serum contained anti-Mt a . The father and all three children phenotyped as Mt a +, while the mother was Mt a -. Adsorption and elution experiments gave results which suggested that anti-Mt a may be implicated in recurrent HDN in this family.
Supporting veterinary clinicians in making evidence-based decisionsIn rabbits does an endotracheal tube or v-gel result in better unassisted ventilation?
Clinical ScenarioYou are a veterinary surgeon anaesthetising a healthy pet rabbit for a routine midline spay. To secure the rabbit's airway you have the choice of using an endotracheal (ET) tube, with an array of different sizes available, or three different sizes of v-gel® (small, medium or large). You sometimes struggle to place an ET tube in rabbits because you do not perform this skill often, and using a mask worries you because the airway is not secured. Your nurse tells you that she does not trust v-gels® and that she does not think they are safe because they cause cyanosis of the tongue and often become misplaced. However, another vet in your practice tells you that v-gels® are quicker and easier to place compared to ET tubes and that they seem to be just as safe and allow good ventilation, but they havent used v-gels® enough to be sure. You wonder whether using v-gel devices results in better unassisted ventilation than using ET tubes in rabbits....
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