Background: Synaptic activity induces translation of mRNAs in dendrites of neurons. Results: Makorin 1 (MKRN1) interacts with poly(A)-binding protein, stimulates translation, accumulates in neuronal dendrites after plasticity-inducing stimuli, and is associated with dendritic mRNAs. Conclusion: MKRN1 has the potential to locally control the translation of dendritic mRNAs at synapses. Significance: MKRN1 is a novel positive regulator of translation.
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