SummaryBackground and objectives Malnutrition, inflammation, atherosclerosis/calcification (MIAC) and endothelial dysfunction are the most commonly encountered risk factors in the pathogenesis of cardiovascular disease in ESRD patients. Epicardial adipose tissue (EAT) is the true visceral fat depot of the heart. The relationship between CAD and EAT was shown in patients with high risk of coronary artery disease. In this study, we aimed to investigate the relationship between EAT and MIAC syndrome in ESRD patients.Design, setting, participants, & measurements Eighty ESRD patients and 27 healthy subjects enrolled in this cross-sectional study. EAT and coronary artery calcification score were measured by a multidetector computed tomography (MDCT) scanner. Patients with serum albumin Ͻ3.5 mg/dl were defined as patients with malnutrition; those with serum C-reactive protein level Ͼ10 ng/dl (normal range, 0 -5 ng/dl) had inflammation; and those with CACS Ͼ10 had atheroscleosis/calcification.Results Total CACS and EAT measurements were significantly higher in ESRD patients when compared with healthy subjects. There was a statistically significant relationship between EAT and CACS in ESRD patients (r ϭ 0.48). EAT measurements were higher in PD patients than HD patients. Twenty-four of the patients had no component, 31 had one component, 17 had two components, and nine had all of the MIAC components. EAT was found to be significantly increased when the presence of MIAC components increased. EAT was positively correlated with age, body mass index, and presence of MIAC. These parameters were also found as independent predictors of increased EAT.Conclusions We found a relationship between EAT and components of MIAC syndrome in ESRD patients.

Background: Atherosclerosis, endothelial dysfunction, coronary artery calcification (CAC), and left ventricular hypertrophy are the most commonly encountered risk factors in the pathogenesis of cardiovascular disease in end-stage renal disease patients. Epicardial adipose tissue (EAT) is the true visceral fat depot of the heart. The relationship between coronary artery disease and EAT has been shown in healthy subjects and patients with a high risk of coronary artery disease. In the present study, we aimed to investigate the relationship between EAT and CAC in peritoneal dialysis (PD) patients. Patients and Methods: Forty-five PD patients (18 females, 27 males, with a mean age of 50.6 ± 15 years) and 25 healthy subjects (12 females, 13 males, with a mean age of 52.4 ± 10.7 years) were enrolled in the study. EAT and CAC score (CACS) measurements were performed by a multidetector computed tomography scanner. Results: EAT of the PD patients was significantly higher than that of the healthy subjects (p = 0.02). When patients were divided into two subgroups (group 1: CACS ≤10, n = 20; group 2: CACS >10, n = 25), EAT was also significantly higher in group 2 patients than in group 1 patients and healthy subjects. Age and EAT were also found to be correlated with CACS ≧10. Conclusion: There is a relationship between the anatomic assessment of coronary artery lesions by multidetector computed tomography and EAT in PD patients. This relationship might be attributed to increased inflammation and proinflammatory cytokines in uremic patients.

Background/aims: Atherosclerosis, coronary artery calcification, diabetes mellitus, inflammation, endothelial dysfunction, and left ventricular hypertrophy are the most commonly encountered risk factors in the pathogenesis of cardiovascular disease in end-stage renal disease (ESRD) patients. Epicardial adipose tissue (EAT) is the true visceral fat depot of the heart. The relationship between coronary artery disease (CAD) and EAT was shown in healthy subjects and patients with high risk of CAD. To date, there is not enough data about EAT in diabetic and nondiabetic ESRD patients. Therefore, we aimed to investigate the EAT and coronary artery calcification score (CACS) in diabetic and nondiabetic ESRD patients and healthy subjects. Methods: Sixty ESRD patients (17 diabetic, 43 nondiabetic ESRD patients) and 20 healthy subjects were enrolled in the study. EAT and CACS were performed by a 64-slice multidetector computed tomography scanner. Results: There were no differences in age, gender, body mass index, predialysis systolic and diastolic blood pressure levels, biochemical parameters including serum low-density lipoprotein and high-density lipoprotein cholesterol, triglycerides, and C-reactive protein between healthy subjects, diabetic, and nondiabetic ESRD patients. Total CACSs and EAT measurements were significantly higher in diabetic ESRD patients when compared with nondiabetic ESRD patients and healthy subjects. There was statistically significant relationship between EAT and CACS in ESRD patients (p < 0.0001, r = 0.48). Conclusion: In conclusion, we found a significant increase in terms of EAT and CACS in diabetic ESRD patients when compared with nondiabetic ESRD patients and healthy subjects.

We found a relationship between PFT and MIAC syndrome in ESRD patients.

Objective Nondipper blood pressure pattern plays an important role in cardiovascular events even in normotensive individuals. The relationship between CRP (C-reactive protein)/albumin ratio (CAR), a valuable marker of inflammation and cardiovascular diseases, has been studied for a long time. We aimed to investigate the relationship between CAR and dipper/nondipper pattern in normotensive subjects.Methods A total of 78 dipper and 78 nondipper participants, based on ambulatory blood pressure monitoring (ABPM), were retrospectively included in our study. CAR and other parameters of all participants were collected from blood samples taken at the time of monitoring.Results CAR was significantly higher in the nondipper group than dipper group (P = 0.001). CAR was negatively and significantly correlated with nocturnal SBP fall ratio and nocturnal DBP fall ratio (P < 0.001). CRP/albumin ratio was found significantly and independently associated with the nondipper pattern (P = 0.002). ConclusionWe found that normotensive individuals with nondipping pattern tend to have increased CAR. Increased inflammatory response could contribute to increase in the atherosclerotic risk in nondippers compared with dippers even in a normotensive profile.

Vascular calcification and increased oxidative stress are commonly seen in patients with end-stage renal disease (ESRD). Nitrotyrosine is one of the end products of nitric oxide metabolism and is

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Amaç: Bu makalenin amacı, kadın hemşireler arasında serviks kanseri tarama ve insan papilloma virüsü (HPV) farkındalık düzeyini ve bilgi ve uygulamalarını etkileyen olası faktörleri araştırmaktır. Gereç ve Yöntemler: Türkiye'deki iki hastanede çalışan hemşirelere, dört bölümden oluşan bir anket formunu elektronik ortamda yanıtlamaları istenerek kesitsel bir araştırma yapılmıştır. Anket, HPV bulaşma, aşılanma ve önleme yöntemleri, serviks kanseri risk faktörleri ve semptomları gibi konulara odaklanan 27 sorudan oluşmaktadır. Toplam 260 hemşire çalışmaya katılmış ve sürekli değişkenler için ortalama ve standart sapma, kategorik değişkenler için ise frekans ve yüzde gibi betimsel istatistikler rapor edilmiştir. Bulgular: Katılımcıların %35.4'ünün jinekolojik muayene yapılması konusunda tereddütleri olduğunu ve %64.6'sının son beş yıl içinde smear testi yaptırmadığını göstermiştir. Ayrıca, %75.4'ünün son beş yıl içinde HPV testi yaptırmadığı saptanmıştır. Yaşın ilerlemesiyle birlikte, HPV farkındalığı, smear ve HPV testleri sıklığı artmakta ve bu farkın istatistiksel olarak anlamlı olduğu bulunmuştur. Hastane tipi ile HPV aşısı hakkındaki bilgi arasında istatistiksel bir ilişki bulunmamışken, evli olan hemşireler aşı hakkında daha fazla bilgi sahibi olmuş ve bekâr hemşirelere göre daha sık smear ve HPV testi yaptırmışlardır. Sonuç: Bu çalışmanın bulguları, serviks kanseri önleme ve tarama programlarını geliştirmeye, HPV farkındalığını artırmaya ve kadınlar için daha iyi sağlık sonuçlarını teşvik etmeye yardımcı olabilir.