BackgroundExcessive weight is a well-known risk factor for microvascular diseases. Changes in thickness in a vascular tissue, such as the choroid, can be useful to evaluate the effect of obesity on the microvascular system. The aim of this study was to evaluate the choroidal thickness (CT) changes in obese women, using optical coherence tomography (OCT).MethodsThe prospective clinical study included examination of the right eyes of 72 patients. The right eyes of 68 patients were examined and served as the controls. A complete ophthalmological examination and OCT imaging were performed for each group studied. The CT in each eye was measured using OCT.ResultsThe obese group consisted of 72 female patients with a mean age of 37.27 ± 1.18 years. The control group included 68 female subjects with a mean age of 37.85 ± 7.98 years (p > 0.05). There was no statistical significant difference for the foveal retinal thickness measurements between the two groups (p > 0.5). Our study revealed significant choroidal tissue thickening subfoveally and at areas 500 μm temporal, 500 μm nasal, and 1500 μm nasal to the fovea in the obese group (all p < 0.05). There was a positive correlation between body mass index (BMI) and CT changes.ConclusionsCT may increase in obese women and a positive correlation was found between BMI and CT.The trial protocol was approved by the Local Ethical Committee of the Kırıkkale University, date of registration: April 27, 2015 (registration number: 10/11).

BackgroundTo assess corneal endothelial cell changes after intravitreal dexamethasone (DEX) implant (Ozurdex®) injection in patients with macular edema secondary to retinal vein occlusion (RVO).MethodsTwenty-two eyes of 22 patients were assessed prospectively after intravitreal 0.7 mg DEX implant injection. Twenty-two eyes of 22 healthy volunteers served as control group. Corneal endothelial cell parameters including endothelial cell density (ECD), coefficient of variation of cell size (CV), percentage of hexagonality (Hex) and central corneal thickness (CCT) were analyzed before and 1 and 3 months after injection by specular microscopy. The results of the study were compared statistically.ResultsThere were 17 (77.3%) patients with branch RVO and 5 (22.7%) patients with central RVO. Mean intraocular pressure (IOP) was 14.73 mmHg before injection, 17.05 mmHg at 1 month and 17.15 mmHg at 3 months after injection. Mean IOP at 1 and 3 months were significantly higher than pre-injection value (p = 0.002 and p = 0.003, respectively). There was a statistically significant reduction in mean ECD at 3 months after injection compared to pre-injection and 1 month (p = 0.013, p = 0.009, respectively) in the injected eyes. Mean ECD showed no significant difference in the uninjected fellow eyes during the follow up (p>0.05). Mean CV and Hex did not reveal a statistically significant difference in injected and uninjected fellow eyes (p > 0.05). No significant change was observed in mean CCT values during the follow up (p = 0.8).ConclusionIntravitreal dexamethasone implant may cause a transient reduction in corneal endothelial cell density in short term without changing cell morphology.

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A 31 year old female patient had decreased vision in her left eye for several months. Visual acuity was 20/20 in right eye and counting fingers from 2 m in left eye. Examination of left eye demonstrated massive macular exudation with grayish discoloration of central macula and, aneurysmal and telangiectatic vessels with surrounding exudation in temporal mid peripheral retina. Optical coherence tomography of left eye showed findings consistent with neovascular complex, pigment epithelial detachment, subretinal fluid and involvment of choroid. There was hyperfluorescent focus with perfusing retinal arteriole and draining venule at the fovea which was compatible with retinal angiomatous proliferation (RAP) in early phase fundus fluorescein angiography and leakage was observed in late phase. After 3 doses of monthly-injected intravitreal ranibizumab and argon laser photocoagulation applied on aneurysmal and telangiectatic vessels, we observed central macular fibrosis, minimal lipid exudation and no macular edema. So retinal angiomatous proliferation may be a feature of adult onset Coats' disease.

tarihleri arasında açık glob yaralanması nedeniyle başvuran 53 hastanın 53 gözünü epidemiyolojik açıdan retrospektif olarak incelemek. Gereç ve Yöntem: Hasta bilgileri hasta dosyaları taranarak kaydedildi. Çıkarılan hasta verileri yaş, cinsiyet, travma türü (keskin/künt), yer ve travmanın şekli ve hangi gözde olduğu şeklindeydi. Başvuru anındaki ve en son andaki görme keskinliği Snellen'in görme keskinliği çizelgesi kullanılarak kaydedildi. Dilate fundus bulgularını da kapsayan biyomikroskobik muayeneler ayrıntılı olarak not edildi. Bulgular: Hastaların 43'ü (%81,1) erkek, 10'u (%18,9) kadındı. Cinsiyet açısından karşılaştırıldığında açık glob travması erkek hastalarda kadın hastalara göre istatistiksel olarak daha yüksekti (p<0.001). Hastaların yaşı arttıkça açık glob yaralanması insidansının azaldığı görüldü. Travmaların %54,7'si iş kazası, %22,6'sı ev kazası, %7,5'i trafik kazası, %13,2'si ev ve iş dışında, %1,9'u ise spor yaparken gerçekleşen kazalardı. Sonuç: Açık glob yaralanmalarının tedavi sonuçları hastalar için yüz güldürücü değildir ve bu tip yaralanmaların çoğunluğu önlenebilir sebeplerden meydana gelmektedir. İş güvenliğine verilecek önem ve toplumun bu konudaki farkındalığını arttıracak eğitimler bu tür yaralanmaların oranını azaltabilir.