Background: Antibodies towards Preferentially Expressed Antigen in Melanoma (PRAME) have shown promise to discriminate between melanoma in situ (MIS) and benign melanocytic lesions. Paget's disease, extramammary Paget's disease, and squamous cell carcinoma in situ may mimic the morphologic features of MIS, and PRAME expression in these lesions has not yet been described.Methods: Three cases of Paget's disease, 11 of extramammary Paget's disease, 15 squamous cell carcinoma in situ cases, and two collision tumors (extramammary Paget's disease and squamous cell carcinoma in situ) were entered into this study.Results: One of 15 cases of squamous cell carcinoma in situ showed focal, weak PRAME positivity. One case of Paget's disease of the breast showed weak, diffuse positivity as did one collision tumor. Five of 11 cases of extramammary Paget's disease displayed positive nuclear PRAME staining with three showing various degrees of cytoplasmic positivity (negative nuclear staining). Conclusions:Although PRAME has shown utility in the diagnosis of MIS, it is not lineage specific. PRAME shows variable expression in mimickers of MIS, and other immunostains should be used to confirm the diagnosis of pagetoid lesions. Positive PRAME staining does seem to suggest a non-squamous tumor lineage, however.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.