The determination of the enantiomeric purity of planar chiral Cr(CO) 3 complexes of substituted benzaldehydes and nitrones has been conveniently carried out by 1 H NMR analysis using a TRISPHAT salt as a diamagnetic chiral shift reagent.
Since the report of a beneficial effect of osanetant in schizophrenic patients, major pharmaceutical companies have been involved in this field, leading to a very large number of patent applications disclosed. Nevertheless, only three NK(3) selective antagonists entered into Phase II, but were then terminated for various reasons. Currently, the main challenge to move forward a selective NK(3) antagonist into the clinic would be to define a safety margin between the desired therapeutic effect and the effect on testosterone levels. The involvement of NKB-NK(3) signaling in reproduction in humans may also lead to new exciting indications, such as treatment for sex steroid-sensitive cancers of breast and prostate.
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