Background and Aims: Women in the childbearing period on hemodialysis (HD) have decreased fertility when compared with the general population. However, pregnancy in this patients’ population is still possible. The aim of the current study was to assess the conception rate in Egyptian HD females. Methods: The study comprises 2 phases: phase one studied the frequency of conception in HD females in Egypt, while phase two studied the live birth frequency and factors affecting it in 22 hemodialysis units (HDUs) including 211 females with sexually active partner in their childbearing period comprising 33 females with HD coincidental pregnancies. Results: 5-year conception rate was 5.2%, and was associated with higher planned dialysis dose (higher blood flow rate, larger dialyzer size, and session length), better control of blood pressure, as well as a lower level of serum ferritin. Live birth frequency was 33.3% and was statistically significantly associated with younger age of the pregnant lady, higher length of dialysis sessions, lower serum phosphorus level, and suggested better nutrition. There was no maternal mortality associated with HD coincidental pregnancies. There was a better neonatal outcome observed with the caesarian section. Conclusion: Fertility is possible and safe in Egyptian HD female with a sexually active partner as there is no maternal mortality but not as such for the fetal outcome. Better conception potentials and the outcome are related to better-planned dialysis dosing and adequate control of phosphate and inflammation.
concentration on chronic dialysis patients were lower than normal population. Some of uremic symptoms are quite similar to that of zinc deficiency. In the current study we measured serum zinc concentration of chronic dialysis patients and evaluated the relationship between the zinc concertation and the nutritional status and QOL. Methods: 556 chronic dialysis patients from 3 dialysis centers in the Yabuki Hospital group were enrolled in the current study. We measured serum zinc concentration before the first dialysis session in a week. Nutritional status was evaluated by the Malnutrition-Inflammation-Score (MIS) system. QOL was evaluated by our original QOL assessment sheet, the POD sheet, as previously published in Nephrol Dial Transplant (2018)33: iii2-iii21. The relationship between the serum zinc concentration and the MIS score and POD score were evaluated by the simple correlation coefficient and chisquare test. Some of the patients were treated with Zinc supplementation. Results: The average zinc concentration was 61.8 micro-gram/dL (normal range: 31-134), and 49.8 % of the patients were diagnosed as "zinc deficiency", 39.8% were diagnosed as "occult zinc deficiency" Most of the patients who were not treated with zinc supplementation were zinc deficiency or occult zinc deficiency. Low serum zinc concentration was significantly correlated with low albuminemia, low phosphatemia, low triglyceride and high CRP. Body fat mass was lower in low Zinc concentration group. Some of dialysis related symptoms were correlated to the serum zinc concentration. Arthralgia and sleep disturbance were related to low zinc concentration. Conclusions: Most of chronic dialysis patients had zinc deficiency or occult zinc deficiency. Low serum zinc concentration was related to the signs of malnutrition and inflammation and also related to some of dialysis related symptoms. Our study was an observational study including the patients treated with zinc supplementation, so prospective controlled trial focusing nutritional status and QOL would be needed.Introduction: Women of childbearing age on conventional hemodialysis (HD) had decreased fertility when compared with the general population, although it is not impossible. Furthermore, in women who conceived, maternal and fetal morbidity and mortality remained elevated. Only few publications addressed the status of pregnancy in HD females in Egypt. Thus, the aim of the current study was to assess the frequency and consequences of conception rate in Egyptian HD females. Methods: The study comprised 2 phases: Phase one investigated the frequency of conception in hemodialysis females in 291 HD units all over Egypt, while phase two studied the consequences of conception and factors affecting its fate in 22 HD units comprising 211 married females in their childbearing period. Results: The 5-year conception rate was 5.2%, and was associated with higher dialysis blood flow rate, larger dialyzer size, longer session length, better control of blood pressure, as well as lower level of serum ferriti...
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