Identifying the influential spreaders in complex networks is crucial to understand who is responsible for the spreading processes and the influence maximization through networks. Targeting these influential spreaders is significant for designing strategies for accelerating the propagation of information that is useful for various applications, such as viral marketing applications or blocking the diffusion of annoying information (spreading of viruses, rumors, online negative behaviors, and cyberbullying). Existing methods such as local centrality measures like degree centrality are less effective, and global measures like closeness and betweenness centrality could better identify influential spreaders but they have some limitations. In this paper, we propose the HybridRank algorithm using a new hybrid centrality measure for detecting a set of influential spreaders using the topological features of the network. We use the SIR spreading model for simulating the spreading processes in networks to evaluate the performance of our algorithm. Empirical experiments are conducted on real and artificial networks, and the results show that the spreaders identified by our approach are more influential than several benchmarks.

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Summary With the constant rise of data volumes in many disciplines, various new Big data management systems have emerged to provide scalable tools for efficient data integration, processing, and analysis. In this article, we provide an overview of biomedical data integration systems focusing on ontology‐based semantic systems and Big data technologies based systems such as Apache Spark. We also propose a new semantic data integration system, called Integrated Proteomics Data System (IPDS), which uses a mediator approach. IPDS provides users a unified interface for query processing and data exploration. This system takes advantage of the Apache Spark framework to perform the query transformation and execution needed to question the integrated data sources. We develop a domain ontology that allows the user to formulate its queries in terms defined in the ontology. IPDS is a case study of semantic proteomics data integration linking four data sources UniProt (protein annotation), String (protein‐protein interaction), PDB (protein structure), and Pubmed (biomedical citation).

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