Diltiazem infusion which started prior to harvesting provided higher IMA blood flow compared to nitroglycerin infusion. Considering the percentage of increases in flows after resection of distal segment, the most prone part to vasospasm, we assume that a certain amount of spasm occurred in IMA in spite of infusion of study drugs, such that less with diltiazem and more with nitroglycerin. Diltiazem plays more important role than nitroglycerin in the prevention of vasospasm.
The results suggest that 0.3 mg x kg(-1) of rocuronium may be a better low dose than 0.15 mg x kg(-1) of rocuronium for clinically acceptable intubating conditions in pediatric ambulatory surgery during remifentanil-propofol-based anesthesia at the doses used in the study.
SummaryFour observers estimated the weight and height of 38 patients who were lying covered on operating theatre trolleys. Regression analysis of the results was performed for each observer. The results showed marked variation in ability to assess these characteristics accurately.
Background: Acute myocardial infarction (AMI) remains as one of the most common lethal diseases in the world and therefore it is necessary to understand its effect on molecular basis. Genome-wide microarray analysis provides us to predict potential biomarkers and signaling pathways for this purpose.Objectives: The aim of this study is to understand the molecular basis of the immediate right ventricular cellular response to left ventricular AMI.Material and Methods: A rat model of left anterior descending coronary artery ligation was used to assess the effect of left ventricular AMI on both the right ventricle as a remote zone and the left ventricle as an ischemic/infarct zone. Microarray technology was applied to detect the gene expression. Gene Ontology and KEGG pathways analysis were done to identify effected pathways and related genes.Results: We found that immune response, cell chemotaxis, inflammation, cytoskeleton organization are significantly deregulated in ischemic zone as early response within 30 min. Unexpectedly, there were several affected signaling pathways such as cell chemotaxis, regulation of endothelial cell proliferation, and regulation of caveolea regulation of anti-apoptosis, regulation of cytoskeleton organization and cell adhesion on the remote zone in the right ventricle.Conclusion: This data demonstrates that there is an immediate molecular response in both ventricles after an AMI. Although the ischemia did not histologically involve the right ventricle; there is a clear molecular response to the infarct in the left ventricle. This provides us new insights to understand molecular mechanisms behind AMI and to find more effective drug targets.
Bu çalışmada açık kalp ameliyatlarında perkütan internal jugüler ven kanülasyonunun kullanımı değerlendirildi ve kullanılan kanül ve işlemle ilgili deneyimlerimiz bildirildi. Ça lış mapla nı:Şubat 2010-Ekim 2012 tarihleri arasında perkütan internal jugüler ven kanülasyonu ile ameliyat edilen 42 hasta (23 erkek, 19 kadın; ort. yaş 45±21.9 yıl; dağılım 2-82 yıl) retrospektif olarak değerlendirildi. Arteriyel kullanım için tasarlanmış Edwards ® Fem-Flex II perkütan femoral arter kanülleri kullanıldı. Kanülasyonlar Seldinger tekniği ile perkütan olarak yapıldı. Vücut yüzey alanı 1.7 m 2 altında olan erişkinlerde 16 Fr, 1.7 m 2 üstünde olan erişkinlerde 18 Fr kanüller kullanıldı. Hastaların 25'i minimal invaziv kalp cerrahisi yapılan hastalar, 17'si tekrar ameliyat gerektiren hastalardı. Superior vena kava drenajının yeterliliğini izlemek için sol internal jugüler venden ilerletilen kanüller ile santral venöz basınç kaydedildi. Bul gu lar: Çalışma grubunda hastane mortalitesi gözlenmedi. Tüm olgularda internal jugüler ven kanülasyonu majör bir perkütan komplikasyon olmadan başarı ile yapıldı. Üç hastada femoral ven kanülü tam yerleştirilemediği için medyan sternotomi sonrası ek atriyal kanül gerekti. On altı ve 18 Fr kanül konulan erişkin hastalar arasında santral ven basıncı ve vakum kullanılması açısından anlamlı bir fark gözlenmedi. So nuç:Femoral arter kanüllerinin internal jugülerden perkütan uygulanması, teknik olarak kolaydır ve ciddi bir komplikasyona yol açmadan uygulanabilir. Ayrıca superior vena kavanın yeterli drenajını sağlamakta ve sağ taraflı kardiyak yapıların atriyumun açılmasını gerektiren işlemlerin periferik vasküler kanüllerle yapılabilmesine olanak vermektedir. Anah tar söz cük ler: Kanülasyon; ekstrakorporeal dolaşım; internal jugüler ven; perkütan. Background: In this study, we evaluated the use of percutaneous internal jugular vein cannulation for open cardiac surgeries and reported our experience on the cannulation and the procedure. Methods: Between February 2010 and October 2012, 42 patients (23 males, 19 females; mean age 45±21.9 years; range 2-82 years) who were operated through percutaneous internal jugular vein cannulation were retrospectively analyzed. An Edwards ® Fem-Flex II percutaneous femoral artery cannula which was designed for arterial procedures was used. Cannulation was performed percutaneously with the Seldinger technique. Sixteen Fr cannulas were used for adults with a body surface area less than 1.7 m 2 , while 18 Fr cannulas were used for patients adults with a body surface area above 1.7 m 2. Minimally invasive cardiac surgery was performed on 25 patients, whereas redo operations were required in 17 patients. Central venous pressure was recorded by cannulae which were advanced through the left internal jugular vein to monitor the adequacy of superior vena cava drainage. Results: No hospital mortality was observed in the study group. Internal jugular venous cannulation was accomplished without a major percutaneous complication in all patients. An additional atrial cannula...
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