Previous incidental findings of an increase of suicidal risk among subjects with low cholesterol levels have drawn attention to the role of lipids in suicidal behavior. To date, multiple lines of evidence acquired from clinical studies have confirmed an association between low cholesterol levels and suicidal behavior, but the involvement of dimensional traits including impulsivity and aggression in this association remains elusive. In this narrative review, we aimed to address and synthesize the literature regarding the involvement of lipids in the neurobiology of suicidal behavior and its underlying psychological substrates, impulsivity and aggression. An electronic database search was performed using different combinations of relevant keywords. Both preclinical and clinical studies matching the scope of this article were reviewed and filtered through an inspection of the abstracts to recruit the most suitable articles that contributed essential and substantial findings to the literature. Although subject characteristics and study designs vary across studies, current research has demonstrated that impulsivity and aggression might have shared neurobiologic substrates involved in altered serotonergic neurotransmission. Despite the association between low serum lipid levels and suicidal behavior being well documented, the involvement of lipid subtypes in the pathophysiology of impulsive and aggressive traits remains elusive. Further work is warranted to recognize the roles of lipids in neuronal membrane functions and serotonin metabolism, promote a greater appreciation of identifying biomarkers that could be used to determine at-risk individuals, and develop potential interventions to disrupt the pathogenesis of behavioral phenotypes of suicide.
Coronavirus infection (COVID-19) caused by the new coronavirus SARSCoV-2 is a global public health problem. Ascorbic acid (vitamin C) is low-cost, safe, antioxidant, anti-inflammatory, and immunomodulating, and has viral load-reducing effects when taken as a supplement. In addition, vitamin C neutralizes free radicals and protects the body against cellular damage, and it can provide a protective effect against cardiovascular diseases by regulating the production of free radicals via nitric oxide. This situation makes ascorbic acid a notable treatment candidate for preventing the worsening of COVID-19. In our case, we present a patient who had a brief psychotic episode following ingestion of high-dose vitamin C due to fear of getting infected with SARS-CoV-2. The psychotic episode may have developed due to increased levels of circulating vitamin C in the central nervous system, which may affect dopamine and GABA levels and changes in NMDA receptor function in the brain. We aim to draw attention to possible neurotoxicity and inflammation caused by free radicals on neuropsychiatric diseases. [ Psychiatr Ann . 2022;52(10):442–444.]
Many psychiatric diseases may be accompanied by dissociative symptoms and disorders. This study examined whether dissociative symptoms affect the response to venlafaxine treatment for major depressive disorder (MDD). The study included 40 patients who had a diagnosis of MDD according to Diagnostic and Statistical Manual of Mental Disorders (fifth edition) criteria. Venlafaxine was administered to each patient (37.5 mg to 150 mg daily) for 10 weeks. The researchers used the Beck Depression Inventory (BDI) and the Dissociation Questionnaire (DIS-Q) on cases with MDD at the beginning of the study. The researchers divided the patients into two groups according to DIS-Q scores and conducted the BDI again at the end of the 10-week period. The authors detected the difference between the values of decrease in BDI scores as a percentage. They found these values to be 48.03% ± 29.03 in the low DIS-Q group and 27.06% ± 32.91 in the high DIS-Q group. They also found a significant difference between the groups (z = −2.167; P = .030). This study showed that, in patients with MDD, intense dissociative experiences reduced the response to venlafaxine therapy. [ Psychiatr Ann 2022;52(3):119–125.]
Previous incidental findings of an increase of suicidal risk among subjects with low cholesterol levels have drawn attention to the role of lipids in suicidal behavior. To date, multiple lines of evidence acquired from clinical studies have confirmed an association between low cholesterol levels and suicidal behavior, but the involvement of dimensional traits including impulsivity and aggression in this association remains elusive. In this narrative review, we aimed to address and synthesize the literature regarding the involvement of lipids in the neurobiology of suicidal behavior and its underlying psychological substrates, impulsivity and aggression. An electronic database search was performed using different combinations of relevant keywords. Both preclinical and clinical studies matching the scope of this article were reviewed and filtered through an inspection of the abstracts to recruit the most suitable articles that contributed essential and substantial findings to the literature. Although subject characteristics and study designs vary across studies, current research has demonstrated that impulsivity and aggression might have shared neurobiologic substrates involved in altered serotonergic neurotransmission. Despite the association between low serum lipid levels and suicidal behavior being well documented, the involvement of lipid subtypes in the pathophysiology of impulsive and aggressive traits remains elusive. Further work is warranted to recognize the roles of lipids in neuronal membrane functions and serotonin metabolism, promote a greater appreciation of identifying biomarkers that could be used to determine at-risk individuals, and develop potential interventions to disrupt the pathogenesis of behavioral phenotypes of suicide.
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