BackgroundNesfatin-1 is a protein derived from a precursor molecule of the nucleobindin-2 gene, and acts as an anorexigenic peptide on food intake behavior, and its level isinfluenced by nutritional status, food composition [fat and carbohydrate (CHO)], and physical exercise.ObjectivesThe aim of this study was to investigate the effects of 6 weeks of treadmill running (at high intensity) program with and without zizyphus jujuba (high carbohydrate content) crud extraction on liver nesfatin-1, ATP, glycogen, and its plasma concentrations in female rats.Materials and MethodsTwenty-eight Wistar female rats (6-8 weeks old100-120 g of weight) were randomly assigned to saline-control (SC), saline-training (ST), zizyphus jujuba-control (ZJC), and zizyphus jujuba-training (ZJT) groups. Rats ran on a motor-driven treadmill at 35 m/min, 60 min/day, 5 days/week for 6 weeks. Animals received ZJ extraction and saline at the dose of 1.25 mL/100g of body weight. Seventy-two hours after the last training session rats were killed, a portion of liver excited, and plasma was collected for nesfatin-1, ATP, and glycogen measurements. A one-way ANOVA method, and Pearson correlation were employed. P < 0.05 was considered as significant.ResultsA higher and significant liver nesfatin-1 level was found in ZJ groups (p < 0.005), but plasma nesfatin-1 responded differently. Changes in liver nesfatin-1 were accompanied with an increase in liver glycogen,but not ATP contents.ConclusionsThe Findings indicate that higher liver nesfatin-1 and glycogen content by ZJ extraction might be due to the ZJ high CHO content, and it could be consideredas an anti-appetite herb.

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