Aims The EURO-ENDO registry aimed to study the management and outcomes of patients with infective endocarditis (IE). Methods and results Prospective cohort of 3116 adult patients (2470 from Europe, 646 from non-ESC countries), admitted to 156 hospitals in 40 countries between January 2016 and March 2018 with a diagnosis of IE based on ESC 2015 diagnostic criteria. Clinical, biological, microbiological, and imaging [echocardiography, computed tomography (CT) scan, 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT)] data were collected. Infective endocarditis was native (NVE) in 1764 (56.6%) patients, prosthetic (PVIE) in 939 (30.1%), and device-related (CDRIE) in 308 (9.9%). Infective endocarditis was community-acquired in 2046 (65.66%) patients. Microorganisms involved were staphylococci in 1085 (44.1%) patients, oral streptococci in 304 (12.3%), enterococci in 390 (15.8%), and Streptococcus gallolyticus in 162 (6.6%). 18F-fluorodeoxyglucose positron emission tomography/computed tomography was performed in 518 (16.6%) patients and presented with cardiac uptake (major criterion) in 222 (42.9%) patients, with a better sensitivity in PVIE (66.8%) than in NVE (28.0%) and CDRIE (16.3%). Embolic events occurred in 20.6% of patients, and were significantly associated with tricuspid or pulmonary IE, presence of a vegetation and Staphylococcus aureus IE. According to ESC guidelines, cardiac surgery was indicated in 2160 (69.3%) patients, but finally performed in only 1596 (73.9%) of them. In-hospital death occurred in 532 (17.1%) patients and was more frequent in PVIE. Independent predictors of mortality were Charlson index, creatinine > 2 mg/dL, congestive heart failure, vegetation length > 10 mm, cerebral complications, abscess, and failure to undertake surgery when indicated. Conclusion Infective endocarditis is still a life-threatening disease with frequent lethal outcome despite profound changes in its clinical, microbiological, imaging, and therapeutic profiles.

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The purpose of the present study was to evaluate the relationship between sleep disturbances and depression in the Japanese elderly. Methods: These investigations in the Japanese elderly were carried out with the Geriatric Depression Scale, the Pittsburgh Sleep Quality Index, and questions on restless legs syndrome and nocturnal eating disorder. A total of 2023 people (male: 1008; female: 1015; average age: 74.2 ± 6.3 years) were analyzed by c 2 test and simple and multiple logistic regression. The prevalence of sleep disturbance was 37.3% and that of depression was 31.3%. Female gender and/or older ( ≥ 75 years) age were significantly associated with depression. Characteristics in depressive elderly were poor sleep efficiency, sleep disturbances due to difficulty of initiating sleep (DIS), breathing discomfort, coldness and pain, poor subjective sleep quality and lack of enthusiasm for activities. Sleep disturbances due to using the bathroom, breathing discomfort and coldness and long sleep latency were associated with depression in younger (65-74 years) men. Sleep disturbance due to DIS was associated with depression in older ( ≥ 75 years) men. Sleep disturbance due to pain was associated with depression in younger and older women. Poor sleep efficiency was associated with depression in older women. Poor subjective sleep quality was associated with depression in younger and older men and younger women. Lack of enthusiasm was associated with depression in younger and older men and older women. Restless legs syndrome was statistically significantly associated with depression in younger men. It is concluded that sleep disturbance and depression among the Japanese elderly are closely related symptoms. The features of sleep disturbance with depression differed with sex and age.

As an addendum to our list of 1999 reviewers, 1 I extend special gratitude to the following reviewers whose service rendered on our behalf last year will bear fruit in our Journal this year. The commitment and expertise of these devoted individuals are the foundations upon which our scholarly and scientific excellence rests. Schizophrenia-Associated Idiopathic UnconjugatedHyperbilirubinemia (Gilbert's Syndrome): 3 Case Reports Sir: Idiopathic unconjugated hyperbilirubinemia (Gilbert's syndrome) is a relatively common congenital hyperbilirubinemia occurring in 3% to 7% of the population. [1][2][3] Recently, it was reported that schizophrenic patients showed a significantly higher frequency of hyperbilirubinemia relative to patients with other psychiatric disorders and the general healthy population. 4 However, there has been only one previous case report of Gilbert's syndrome occurring in a schizophrenic patient. 5 We report 3 cases in which patients developed schizophrenia and Gilbert's syndrome and discuss clinical aspects of Gilbert's syndrome in schizophrenic patients and the relationship between hyperbilirubinemia and schizophrenia. Case 1. Mr. A, a 26-year-old single man, was diagnosed with schizophrenia at age 23 and admitted to the Shimane Medical University Hospital (Izumo, Japan). At that time, mild hyperbilirubinemia (total bilirubin level = 2.8 mg/dL, direct bilirubin level = 0.3 mg/dL), predominantly unconjugated, was first diagnosed on a routine laboratory test at admission and led us to suspect Gilbert's syndrome. After admission, Mr. A's psychiatric symptoms were well controlled by neuroleptic treatment. Laboratory tests of blood bilirubin levels showed an improvement 2 weeks after admission (total bilirubin level = 0.5 mg/dL, direct bilirubin level = 0.2 mg/dL). At the age of 26, coincident with discontinuation of antipsychotic medication, Mr. A experienced exacerbation of the psychotic condition and recurrent hyperbilirubinemia (total bilirubin level = 3.4 mg/dL, direct bilirubin level = 0.4 mg/dL) with a diagnosis of Gilbert's syndrome. He was readmitted to the Shimane Medical University Hospital in a severely psychotic state. Mr. A's psychotic condition has improved during the past 6 months with the administration of neuroleptics. Laboratory tests of blood bilirubin levels also showed improvement (total bilirubin level = 0.5 mg/dL, irect bilirubin level = 0.2 mg/dL). Mr. A experienced no relapse of psychotic condition with concomitant re-increase of unconjugated bilirubin levels.Case 2. Mr. B, a 33-year-old single man, was diagnosed with schizophrenia at age 25, at which time treatment with neuroleptics was started. Coincident with the onset of psychosis, hyperbilirubinemia (total bilirubin level = 2.3 mg/dL, direct bilirubin level = 0.3 mg/dL), predominantly unconjugated, was first diagnosed on a routine laboratory test and led us to suspect Gilbert's syndrome. At the age of 30 years, Mr. B experienced exacerbation of the psychotic condition. He was admitted to the Shimane Medical Unive...

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