A clinical trial was carried out to investigate the effect of Anchovy of Stolephorus baganensis on mutans streptococci inhibiting the growth of the salivary mutans streptococci for a period of one week consumption. Before enrolled in the study, respondents filled out and signed the informed consent. Twenty respondents participated as the subjects on the clinical trial, conducting two times of treatment as follows: twenty as treatment groups before and after consuming anchovy of Stolephorus baganensis and the twenty subjects as control groups before and after consuming non-anchovy of Stolephorus baganensis. Saliva samples were collected before and after consuming anchovy of Stolephorus baganensis and with a non-anchovy of Stolephorus baganensis . A serial dilution was made, followed by inoculating on TYS20B medium). Data which were obtained from colony forming units of salivary mutans streptococci grew on the TYS20B medium before and after consuming anchovy of Stolephorus baganensis were analyzed in a descriptive and "t" test. Results showed that there was no significance in the average amount of Streptococcus mutans colonies between before and after consuming non-anchovy of Stolephorus baganensis. However, a significant difference was found respectively as results before and after consuming anchovy of Stolephorus baganensis. We concluded that Anchovy of Stolephorus baganensis has antimicrobial activity against local strains of Streptococcus mutans isolated from human harboring species. Therefore in a long term of consuming Anchovy fish of Stolephorus baganensis, caries can be prevented Keywords: Anchovy of Stolephorus baganensis, Salivary Mutans Streptococci. socially accepted form of oral hygiene. 3 Mouth rinsing and tooth brushing are the principal way for mechanical removal of plaque and to prevent Streptococcus mutans colonized in teeth. 3.4 Anchovy fish of Stolephorus baganensis contains nutritional contents of carbohydrates, proteins, fats, vitamins, and minerals. One of the important nutritional elements in Anchovy fish is the fluoride. The fluoride level in this fish is quite high ranging from 5 to 35 ppm, thereby anticipating that oral health is maintained by regularly consuming Anchovy fish 5 .
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