Anti-sperm antibodies (ASA) are one of the causes of immune infertility, and they are produced in some infertile men and women.In the infertility outpatient clinic, the ASA testing for women, such as sperm-immobilization test (SIT). 1,2 is simple for the clinicians because it requires only the patients' sera. In men, however, the world health organization (WHO) recommend to perform the ASA testing for the detection of sperm-bound antibodies simultaneously during the routine semen examination. 3 Due to the complexity, it has been suggested that the actual examinations of ASA for infertile men are rare. Therefore, the option of testing sperm-immobilizing antibody in the infertile patients' sera is discussed for men and women.However, evaluation of sperm-immobilizing antibody in men's sera did not reveal its clinical significance. 4 In this way, it seems to be generally hard to say that the sex difference in ASA is well recognized. For women, sperm are immunogenic and they do not exist in themselves, and ASA are strictly homologous antibodies. On the contrary, ASA are produced as autoantibodies in men. So far, there have been no reports on the
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.