In the course ot a screening program for tyrosine kinase inhibitors, the chloroform extract of a tropical plant, Desmos chinensis, strongly inhibited the enzyme activity. The active substance was purified by silica gel, gel filtration, and finally crystallized. The structure was elucidated by mass spectrometry and X-ray crystallography to be 8-formyl-2,5,7-trihydroxy-6-methylflavanone, and we named it desmal. Desmal competed with peptide substrate and non-competed with ATP. It inhibited tyrosine kinase in situ in epidennal growth factor (EGF) receptor-overexpressing NIH3T3 (ER12) cells. It also inhibited EGF-induced inositol phosphate formation and morphological changes.
This paper presents a theoretical study of the steady wind-driven currents in a semi-enclosed rectangular basin of uniform depth. Linearlised equations of motion and f-plane approximation are used. Horizontal component of winddriven current has been obtained for a general steady wind system by means of Fourie analysis. Solution is composed of both wind drift and slope current. Calculation reproduced a flow structure similar to the existing field data.
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