A novel, safe, economic and sensitive method of spectrophotometric estimation has been developed using Azeoptropic mixture (water:methanol: 60:40, v/v) for the quantitative determination of Lornoxicam, a practically water-insoluble drug. Hence, Lornoxicam stock solution was prepared in Azeoptropic mixture. Lornoxicam showed maximum absorbance at 383 nm. Beer's law was obeyed in the concentration range 4–24 μg/mL with regression coefficient of 0.999. The method was validated in terms of linearity (R2=0.999), precision (CV for intra-day and inter-day was 0.28–0.68 and 0.12–0.92, respectively), accuracy (98.03–100.59% w/w) and specificity. This method is simple, precise, accurate, sensitive and reproducible and can be used for the routine quality control testing of the marketed formulations.
Poly (disulphido-imides) were prepared by Diels-Alder (DA) reaction of furfuryl-disulphide (FDS) with various bismaleimides. The DA reaction was carried out in xylene as solvent, as well as in bulk, followed by aromatization of terrahydrophthalimide intermediates in the presence of acetic anhydride. All the poly (disulphido-imide)s were characterized by elemental analyses, IR spectral data and thermogravimetry. The poly (disulphido-imide)s exhibit moderate thermal stability. Preliminary test for glass reinforcement of the poly (disulphido-imide) indicate that laminates with good mechanical strength can be obtained.
A novel approach was used to develop a matrix resin for processable poiyimide-glass-fibre composites. Furfural-acetone (FAC) resin, poly(4-Furanyl butan-2-one), and various bismaleimides were polymerized at 140 + 10 and 180+ 10+C by in situ Diels-Alder intermolecular reaction into moderately thermally stable and highly cross-linked polyimide-glass-fibre composites without the evolution oQf by-products. The fabricated composites (i.e. laminates) were characterized by their chemical resistance and mechanical properties
Polyimides were prepared by Diels-Alder (DA) reaction of furfuralacetone (FAC) resin [poly(4-furanyl-butan-2-one)] with various bismaleimides. The DA reaction was carried out in tetrahydrofuran (THF) as solvent as well as in bulk, followed by aromatization of the tetrahydrophthalimide intermediates in the presence of acetic anhydride. All the polyimides were characterized by elemental analysis, IR spectral studies and thermogravimetry. The results show that polyimides based on FAC resin exhibit good thermal stability. Preliminary tests for glass reinforcement of the polyimides indicate that laminates with good mechanical strength can be prepared.
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