Pharmacotherapies that specifically target ammonia for the prevention and treatment of hepatic encephalopathy in adults with cirrhosis.

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Linked Content This article is linked to Greinert et al papers. To view these articles visit https://doi.org/10.1111/apt.13721 and https://doi.org/10.1111/apt.13850.

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Neuronal networks were explored in patients with cirrhosis using advanced EEG computational analysis. Significant disruption of cortical networks was found even in the absence of hepatic encephalopathy. The findings provide new insights into the cortical signature of this syndrome and its pathogenesis.