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The protein content of the plasma of the blood can be calculated from the observed value of the specific gravity of the plasma with sufficient exactness for certain clinical purposes. This correlation was shown by Moore (5) in cirrhosis of the liver, in other diseases in which the liver is involved, in diabetes, in nephritis, and in anemia, and by others. Decreases both in specific gravity and in protein content of the plasma have been shown by Butterfield, Erdwurm and Braddock (6) to be present in nephritis with edema and by Moore and Van Slyke (1) in nephritis with edema, that is to say, in Bright's disease.The physiological variations in the proteins of the plasma and the means by which they may be altered experimentally have not been extensively studied. Greene and Rowntree (7) in 1924 demonstrated that the protein content of serum decreased after forced administra-423

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