The new chlorinated peptides sintokamides A to E (1-5) have been isolated from specimens of the marine sponge Dysidea sp. collected in Indonesia. Their structures were elucidated by a combination of spectroscopic and single-crystal X-ray diffraction analyses. Sintokamide A (1) is an inhibitor of N-terminus transactivation of the androgen receptor in prostate cancer cells.

Sumber daya ikan di perairan Indonesia merupakan salah satu modal menuju kemakmuran bagi bangsa, apabila dikelola secara berkelanjutan.Kajian potensi dan tingkat pemanfaatan tahun 2015, merupakan salah satu dasar utama dalam merumuskan pengelolaan tersebut menuju pemanfaatan sumber daya yang lestari bagi kesejahteraan bangsa. Secara keseluruhan komposisi jenis sumber daya ikan di perairan Indonesia didominasi kelompok ikan pelagis kecil sebesar 36 % dan ikan pelagis besar sebesar 25 %. Potensi sumber daya ikan di perairan Indonesia adalah sebesar 9,931 juta ton per tahun dengan potensi tertinggi terdapat di WPP 718 (Laut Arafura) sebesar 1,992 juta ton/tahun (20%), di WPP 572 (Samudera Hindia sebelah barat Sumatera dan Selat Sunda) sebesar 1,228 juta/tahun (12 %) dan di WPP 711 (Selat Karimata, Laut Natuna dan Laut Cina Selatan) sebesar 1,143 juta ton/tahun (12 %). Tingkat pemanfaatan secara keseluruhan terlihat didominasi kondisi overfishing (indikator warna merah) sekitar 49 %, diikuti kondisi fully-exploited (indkator warna kuning) sekitar 37 % dan kondisi moderat (indikator warna hijau) hanya 14 %. Kelompok ikan yang mengalami kondisi overfishing paling tinggi adalah kelompok udang Penaeid, lobster, kepiting dan rajungan, yang mencapai 63 % dari kondisi overfishing saat ini. Dalam perspektif yang demikian, opsi pengelolaan yang harus segera dilakukan adalah mengurangi jumlah upaya penangkapan pada WPP yang mengalami kondisi overfishing serta meningkatkan upaya pada WPP yang tingkat pemanfaatannya masih moderat dan fully exploited.Fish resources within Indonesian waters (i.e. teritorial and archipelagic waters) including Indonesian Economic Exclusive Zone if under sustainably management it would contribute a significant role as a source of nation welfare. Scientific advice on stock status and its exploitation rate are required as an input to support an apropriate fisheries management. Generally, fish resources in these waters are dominated by two main fish groups such as small pelagic fish by 36 % and large pelagic fish by 25 %. Indonesia fish resource in 2015 was estimated for 9,931 million tons/year with comprises of 1,992 million ton/year (20 %) in fisheries management area (FMA) 718 (Arafura sea), 1,228 million/year (12 %) in FMA 572 (western of Sumatera of Indian ocean and Sunda strait) and 1,143 million tons/year (12 %) in FMA 711 (Karimata strait, Natuna sea, and south China sea). Most of fish resources (49 %) were in the status of overfishing with red indicator, folowed by fully-exploited state(37 %) in yellow indicator and only 14 % in the moderate state (green indicator). Among all nine fish groups, the overfishing state (up to 63%) is recorded from group of shrimps (Penaidae), lobster, and crabs. The management options in these prespective is urgently suggested to reduce fishing effort at the level of f.opt (fishing optimum) for overfishing fish groups. Whilts possibly to increase effort for fish groups with fully and moderate exploited state at the level off opt.

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