Obesity is a health disorder characterized by an increase in body weight, measured by waist circumference. High waist circumference is linked to potential development of non-communicable diseases. A systematic review study was used to explore health risks of high waist circumference through Google Scholar, Science Direct, Pubmed, and Proquest. Findings show that high waist circumference increased the risks of developing hypertension, type 2 diabetes mellitus, hypercholesterolemia, joint pain, low back pain, and hyperuricemia. It is recommended that government increase their role in raising public awareness to maintain healthy lifestyle.

Plant‐derived exosome‐like nanoparticles (PDENs) are small vesicles released by multivesicular bodies mainly to communicate between cells and regulate immunity against pathogen attack. Current studies have reported that PDENs could modulate gene expression in a cross‐kingdom fashion. Therefore, PDENs could be a potential future functional food ingredient as their cross‐kingdom communication abilities were reported to exert multiple health benefits. Macrophage and other cells have been reported to absorb PDENs in a manner regulated by the membrane lipid and protein profile and the intactness of the PDENs lipid bilayer. PDENs could be extracted from plant materials by various techniques such as ultracentrifugation, immunoaffinity, size‐based isolation, and precipitation, though each method has its pros and cons. PDENs mainly contain lipid, protein, and genetic materials, mainly micro RNAs, which could exert multiple health benefits and functionalities when consumed in sufficient amounts. However, most studies on the health functionalities of PDENs were conducted through in‐vitro and in‐vivo studies, and its potency to be used as a functional ingredient remains a question as PDENs are sensitive to storage and processing condition and requires costly extraction method. This concise review features various exosome extraction methods, contents of PDENs and their roles, the health functionalities of PDENs, and its potency as a functional food ingredient.

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The premarital sexual behavior adolescent has become a social problem in the community. Free sexual behavior are various ranging from feeling of attraction to the opposite sex, dating, kissing, holding partsof the body that are sensitive until sexual intercourse. Two factors that can infl uence sexual behavior are knowledge and self control. Adolescent who have high knowledge and self control tend to not perform sexual behavior. The purpose of this study was to analyze the effect of knowledge and premarital sexual behavior self control in adolescent of SMK in Surabaya. This study was performed using cross sectional study design. The study population was students of class XI SMK in Surabaya. Subjects were selected by proportional stratified random sampling. Sample was 83 students. Data analysis was performed using chi square test (α = 0.05). The results of this study were self-control influenced knowledge (p = 0.000; PR = 11.000), knowledge infl uenced premarital sexual behavior (p = 0.000; PR = 10.607) and self-control infl uenced premarital sexual behavior (p = 0.000; PR = 46.970). The conclusion of this research is variables knowledge and self-control infl uence premarital sexual behavior SMK in Surabaya increasing increase knowledge of adolescent in relation to premarital sexual behavior before marriage through counseling in Generation Program Plan (GENRE). Genre was can be a alternative solution to decrease premarital sexual behavior.

Breast cancer is cancer with the number of new cases and deaths highest in Indonesia. According to the Data Center and Information Ministry of a health Indonesia in the year 2013, the number of new cases of breast cancer of 819 and the number of deaths amounted to 217. In general, breast cancer known after stepping on an advanced stage. So the methods of early detection of breast cancer are focused on the detection of early stage tumors that are usually small with self-breast examination (SADARI). The purpose of this research is to predict the factors related to the behavior of self-breast examination (SADARI) the housewives aged 40–50 years. This research is an observational study with cross sectional approach. Sample research totaling 100 people  housewife in Kelurahan Sidotopo Wetan Kenjeran Subdistrict Surabaya. The measurement was done by providing a questionnaire to obtain information about the research variables. Variable independent research is k nowledge, attitudes, information accessibility, support health providers and descent with breast cancer. The results of this research showed the variables that are associated with the  SADARI behavior of the housewifes is attitude (p = 0.000), accessibility of information (p = 0.000), and health care providers support (p = 0.010). The majority of housewives in Kelurahan Sidotopo Wetan Kenjeran Sub-district Surabaya showed a good attitude and support toward SADARI. In the area surrounding the residence h ousewife get access information easily. There are no support for doing SADARI from health care providers.

Introduction. The morbidity and mortality rate of Acute Respiratory Tract Infection (ARI) in children under 5 is relatively high in Indonesia. Socio-demographic characteristic is considered one of the factors causing ARI in Indonesia. However, no study analyzed the prevalence of ARI among toddlers and the differences among the determinant factors in multiple periods. Thus, this study aimed to analyze the prevalence trends and determinant factors associated with ARI symptoms in children under 5 in Indonesia in 2007, 2012, and 2017. Methods. This study analyzed cross-sectional survey data from the Demographic and Health Survey (DHS) in Indonesia during 2007, 2012, and 2017. Bivariate and multivariate analysis with logistic regression was performed using Stata version 15. The final results were expressed in Adjusted Odds Ratio (AORs) and 95% Confidence Interval (CI). Results. The findings showed a progress in prevalence trends with a decrease in the percentage of children with ARI symptoms from 11.25% (2007), then 5.12% (2012) to 4.22% (2017). Risk factors for toddlers experiencing ARI symptoms were as follows: younger maternal age (OR: 1.13, 95% Cl 0.70-1.81 in 2007, OR: 1.72, 95% Cl 1.03-2.88 in 2012 and OR: 0.98, 95% Cl 0.48-1.97 in 2017), smoking habits of family members (OR: 1.12, 95% Cl 0.85-1.48 in 2012, OR: 1.23, 95% Cl in 2017), poor drinking water quality (OR: 1.12, 95% Cl 0.85-1.48 in 2012 and OR: 1.23, 95% Cl in 2017), unavailable toilet facilities (OR: 1.27, 95% Cl 1.04-1.56 in 2007, OR: 1.24, 95% Cl 0.95-1.63 in 2012 and OR: 1.28, 95% Cl 0.97-1.68 in 2017). Conclusion. There was a decrease in the prevalence of ARI symptoms among children in 2007, 2012, and 2017, with no prominent differences in other related factors. The lifestyle and household environmental factors such as the use of dirty fuel, the presence of smokers in the household, the poor quality of drinking water, unavailable toilet facilities in addition to the maternal age and child age were the determinant factors that must be prioritized and improved. Family self-awareness should also be enhanced for better prospects for toddler survival.

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The first positive case of coronavirus disease 2019 (COVID-19) in Indonesia was announced in March 2020. Since then, the positive cases have continued to increase. This condition prompted the government to adopt the Large-Scale Social Restriction (LSSR)/Pembatasan Sosial Berskala Besar (PSBB). Some areas included in endemic regions for dengue face two problems: overcoming COVID-19 and Dengue Hemorrhagic Fever (DHF) simultaneously. Five economic growth center cities/districts in East Java Province (Gresik, Bangkalan, Surabaya, Sidoarjo, and Lamongan) were affected by the COVID-19 pandemic and dengue fever. This was a quantitative research with a comparative design study using the Wilcoxon test to compare the cases of DHF pre-COVID-19 and during the COVID-19 pandemic. The Wilcoxon test result showed no significant difference with a p-value of 0.319 (p-value>0.05). It can be concluded that DHF still becomes a problem in five cities/districts in East Java Province even though LSRR was applied. Extra attention is needed to overcome DHF. One of the efforts to prevent and control DHF during the COVID-19 pandemic is to build community independence through the one house one health cadres’ movement.