Introduction Knowledge of tumor growth is important in the planning and evaluation of screening programs, clinical trials, and epidemiological studies. Studies of tumor growth rates in humans are usually based on small and selected samples. In the present study based on the Norwegian Breast Cancer Screening Program, tumor growth was estimated from a large population using a new estimating procedure/model.
The present study investigates the demographics of same-sex marriages--that is, registered partnerships-in Norway and Sweden. We give an overview of the demographic characteristics of the spouses of these partnerships, study patterns of their divorce risks, and compare the dynamics of same-sex couples with those of heterosexual marriages. We use longitudinal information from the population registers of the two countries that cover all persons in partnerships. Our demographic analyses include information on characteristics such as age, sex, geographic background, experience of previous opposite-sex marriage, parenthood, and educational attainment of the partners involved. The results show that in many respects, the distributions of married populations on these characteristics differ by the sex composition of the couples. Patterns in divorce risks are rather similar in same-sex and opposite-sex marriages, but divorce-risk levels are considerably higher in same-sex marriages. The divorce riskforfemale partnerships is double that for male partnerships.
Objective To evaluate the effectiveness of contemporary mammography screening using individual information about screening history and breast cancer mortality from public screening programmes.Design Prospective cohort study of Norwegian women who were followed between 1986and 2009 . Within that period (1995, a national mammography screening programme was gradually implemented, with biennial invitations sent to women aged 50-69 years.Participants All Norwegian women aged 50-79 between 1986 and 2009. Main outcome measuresMultiple Poisson regression analysis was used to estimate breast cancer mortality rate ratios comparing women who were invited to screening (intention to screen) with women who were not invited, with a clear distinction between cases of breast cancer diagnosed before (without potential for screening effect) and after (with potential for screening effect) the first invitation for screening. We took competing causes of death into account by censoring women from further follow-up who died from other causes. Based on the observed mortality reduction combined with the all cause and breast cancer specific mortality in Norway in 2009, we used the CISNET (Cancer Intervention and Surveillance Modeling Network) Stanford simulation model to estimate how many women would need to be invited to biennial mammography screening in the age group 50-69 years to prevent one breast cancer death during their lifetime.Results During 15 193 034 person years of observation , deaths from breast cancer occurred in 1175 women with a diagnosis after being invited to screening and 8996 women who had not been invited before diagnosis. After adjustment for age, birth cohort, county of residence, and national trends in deaths from breast cancer, the mortality rate ratio associated with being invited to mammography screening was 0.72 (95% confidence interval 0.64 to 0.79). To prevent one death from breast cancer, 368 (95% confidence interval 266 to 508) women would need to be invited to screening. ConclusionInvitation to modern mammography screening may reduce deaths from breast cancer by about 28%.
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