Chiral organic–inorganic hybrid metal halides
have a strong
structure–property relationship, such as that the modification
of their structural dimensionality can adjust their chiroptical properties.
Here, based on chiral organic molecules R/S-methylbenzylamine (R/S-MBA), we synthesized new chiral antimony halides with structures
from zero-dimensional (0D) (R/S-MBA)2SbI5to one-dimensional (1D) (R/S-MBA)SbI4. The chirality transfer from
chiral ligands to the inorganic framework was analyzed based on the
electrical dipole moment of R/S-MBA.
The anisotropy factor of circular dichroism (g
CD) of this 1D chiral (R/S-MBA)SbI4 is determined to be about ∼0.02, which
is about 1 order of magnitude larger than that of the 0D (R/S-MBA)2SbI5.
Objectives:Here, we investigated the inhibitory effects of coenzyme Q0 (CoQ0) on biofilm formation and the expression of virulence genes by Cronobacter sakazakii. Results:We found that the minimum inhibitory concentration of CoQ0 against C. sakazakii strains ATCC29544 and ATCC29004 was 100 μg/mL, while growth curve assays showed that sub-inhibitory concentrations (SICs) of CoQ0 for both strains were 6.4, 3.2, 1.6 and 0.8 μg/mL. Assays exploring the inhibition of specific biofilm formation showed that SICs of CoQ0 inhibited biofilm formation by C. sakazakii in a dose-dependent manner, which was confirmed by scanning electron microscopy and confocal laser scanning microscopy analyses. CoQ0 inhibited the swimming and swarming motility of C. sakazakii and reduced its ability to adhere to and invade HT-29 cells. In addition, CoQ0 impeded the ability of C. sakazakii to survive and replicate within RAW 264.7 cells. Finally, real time polymerase chain reaction analysis confirmed that nine C. sakazakii genes associated with biofilm formation and virulence were down-regulated in response to CoQ0 treatment. Conclusion:Overall, our findings suggest that CoQ0 is a promising antibiofilm agent and provide new insights for the prevention and control of infections caused by C. sakazakii.
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