The impact of stress on the formation and expression of memory is well-studied, especially on the contributions of stress hormones. But how stress affects brain circuitry dynamically to modulate memory is far less understood. Here, we used male C57BL6/J mice in an auditory fear conditioning as a model system to examine this question and focused on the impact of stress on dorsomedial prefrontal cortex (dmPFC) neurons which play an important role in probabilistic fear memory. We found that paraventricular thalamus (PVT) neurons are robustly activated by acute restraining stress. Elevated PVT activity during probabilistic fear memory expression increases spiking in the dmPFC somatostatin neurons which in turn suppresses spiking of dmPFC parvalbumin (PV) neurons, and reverts the usual low fear responses associated with probabilistic fear memory to high fear. This dynamic and reversible modulation allows the original memory to be preserved and modulated during memory expression. In contrast, elevated PVT activity during fear conditioning impairs synaptic modifications in the dmPFC PV-neurons and abolishes the formation of probabilistic fear memory. Thus, PVT functions as a stress sensor to modulate the formation and expression of aversive memory by tuning inhibitory functions in the prefrontal circuitry.Significance Statement:The impact of stress on cognitive functions, such as memory and executive functions, are well-documented especially on the impact by stress hormone. However, the contributions of brain circuitry are far less understood. Here we show that a circuitry-based mechanism can dynamically modulate memory formation and expression, namely, higher stress-induced activity in paraventricular thalamus impairs the formation and expression of probabilistic fear memory by elevating the activity of somatostatin-neurons to suppress spiking in dorsomedial prefrontal parvalbumin neurons. This stress impact on memory via dynamic tuning of prefrontal inhibition preserves the formed memory but enables a dynamic expression of memory. These findings have implications for better stress coping strategies as well as treatment options including better drug targets/mechanisms.
In order to study the influence of aero-optical effects on the detection system of hypersonic vehicles, a set of numerical simulation system is developed for simulating the whole process of aero-optical effects. With the design scheme of "system platform plus simulation function module plus data storage", the development work for the platform and function modules are accomplished in Qt5 development environment. Users can create simulation tasks and complete simulations according to their needs. The system has good scalability and supports users to develop new functional modules according to the interface specifications. The simulation results of this system can provide theoretical basis for theoretical research and engineering application of aero-optical effects.
In the current study, the influence of different rotation conditions on the flow behavior is experimentally investigated by a new system which is designed for time-resolved PIV measurements of the smooth channels at rotation conditions. The Reynolds number equals 15000 and the rotation number ranges from 0 to 0.392 with an interval of 0.098.
This new time-resolved Particle Image Velocimetry system consists of a 10 Watts continuous laser diode and a high-speed camera. The laser diode can provide a less than 1mm thickness sheet light. 6400 frames can be captured in one second by the high-speed camera. These two parts of the system are fixed on a rotating disk. In this case, the relative velocity of flows in the rotating smooth square channel can be measured directly to reduce the measurement error. This system makes high-speed camera close to the rotating channel, which allows a high resolution for the measurements of main stream. In addition, high accuracy and temporal resolution realize a detailed analysis of boundary layer characteristics in rotation conditions. Based on this system, experimental investigation has been undertaken. Results are presented of the evolution of velocity and boundary layer thickness at various rotation numbers and different circumferential positions.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.