On account of high energy density and low cost of sulfur, lithium‐sulfur (Li−S) battery has been regarded as an appealing energy storage system to date. Nevertheless, it has faced formidable challenges, mainly pertaining to the fatal shuttle effect and retarded sulfur redox kinetics. Single atom catalysts (SACs) have showcased great promise for addressing these issues owing to their maximum atom utilization efficiency, favorable catalytic activity as well as their good structural tunability at an atomic level, considerably contributing to the recent fruitful advancements in Li−S realm. In this review, we summarize the state‐of‐the‐art strategies in the coordination manipulations of SACs toward highly efficient and durable Li−S batteries. The recent advances, existing issues, and future outlooks are discussed accordingly, aiming to guide the synthetic design of SACs, propel the underlying mechanism understanding and ultimately boost the commercial viability of Li−S batteries.