Background
Models predicting future macrovascular invasion in hepatocellular carcinoma are constructed to assist timely interventions.
Methods
A total of 366 HCC cases were retrospectively collected from five Chinese hospitals between April 2007 and November 2016: the training dataset comprised 281 patients from four hospitals; the external validation dataset comprised 85 patients from another hospital. Multi-task deep learning network-based models were constructed to predict future macrovascular invasion. The discrimination, calibration, and decision curves were compared to identify the best model. We compared the time to macrovascular invasion and overall survival using the best model and related image heterogeneity scores (H-score). Then, we determined the need for a segmentation subnet or the replacement deep learning algorithm by logistic regression in screening clinical/radiological factors. Finally, an applet was constructed for future application.
Findings
The best model combined clinical/radiological factors and radiomic features. It achieved best discrimination (areas under the curve: 0·877 in the training dataset and 0·836 in the validation dataset), calibration, and decision curve. Its performance was not affected by the treatments and disease stages. The subgroups had statistical significance for time to macrovascular invasion (training: hazard ratio [HR] = 0·073, 95% confidence interval [CI]: 0·032–0·167,
p
< 0·001 and validation: HR = 0·090, 95%CI: 0·022–0·366,
p
< 0·001) and overall survival (training: HR = 0·344, 95%CI: 0·246–0·547,
p
< 0·001 and validation: HR = 0·489, 95%CI: 0·279 – 0·859,
p
= 0·003)
.
Similar results were achieved when the patients were subdivided by the H-score. The subnet for segmentation and end-to-end deep learning algorithms improved the performance of the model.
Interpretation
Our multi-task deep learning network-based model successfully predicted future macrovascular invasion. In high-risk populations, besides the current first-line treatments, more therapies may be explored for macrovascular invasion.
The thyroid gland secretes indispensable hormones that are necessary for all the cells in your body to work normally. In order to diagnose and treat thyroid cancer at the earliest stage, it is desired to characterize the nodule accurately. We proposed cascade UNet and CH-UNet to segment thyroid nodules and classify benign and malignant thyroid nodules, respectively. Cascade UNet consists of UNet-I and UNet-II, which segment the nodules in the image at uniform resolution and original resolution, respectively. CH-UNet takes segmentation as an auxiliary task to improve classification performance. We verified our method on the test set of the TNSCUI 2020 Challenge. We achieved 81.73% IoU on segmentation and 0.8551 F1 score on classification, which won the first place in the classification track and was only 0.81% IoU away from the first place in the segmentation track.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.