No abstract

Background: With rapid development in molecular biology techniques and a greater understanding of cancer pathogenesis, the growing attention has been concentrated on cancer gene therapy, with numerous articles on this topic published in recent 5 years. However, there is lacking a bibliometric analysis of research on cancer gene therapy. Therefore, the aim of the present study was to conduct a bibliometric analysis to provide the trends and frontiers of research on cancer gene therapy during 2016–2020.Methods: We utilized CiteSpace 5.7.R5 software to conduct a bibliometric analysis of publications on cancer gene therapy published during 2016–2020. The bibliometric records were obtained from the Web of Science Core Collection.Results: A total of 4,392 papers were included in the bibliometric analysis. Materials Science and Nanoscience and Nanotechnology took an increasing part in the field of cancer gene therapy. Additionally, WANG W was the most productive author, while ZHANG Y ranked top in terms of citations. Harvard Medical School and Sichuan University ranked top in the active institutions. P NATL ACAD SCI USA was identified as the core journal in the field of cancer gene therapy. “Ovarian cancer” was found to be the latest keyword with the strongest burst. The keyword analysis suggested that the top three latest clusters were labeled “gene delivery,” “drug delivery,” and “gene therapy.” In the reference analysis, cluster#2 labeled “gene delivery” held a dominant place considering both the node volume and mean year.Conclusion: The academic attention on cancer gene therapy was growing at a dramatically high speed. Materials Science and Nanoscience and Nanotechnology might become promising impetus for the development of this field. “Gene delivery” was thought to best reflect the research frontier on cancer gene therapy. The top-cited articles on gene delivery were focused on several novel non-viral vectors due to their specialty compared with viral vectors. “Ovarian cancer” was likely to be the potential research direction. These findings would help medical workers conduct further investigations on cancer gene therapy.

Abstract-Although the Almost Blank Subframes (ABSF) proposed in heterogeneous cellular networks can enhance the performance of the Cell Range Expansion (CRE) User Equipments (UEs), it significantly degrades macro-cell total throughput. To address this problem, the Low Power Subframes (LPSF) are encouraged to be applied in macro-cell center region by the Further-enhanced Inter-cell Interference Coordination (FeICIC). However, the residual power of the LPSF which interferes the CRE UEs, and the proportion of the LPSF affect the downlink throughput together. To achieve a better rate coverage probability, appropriate LPSF power and proportion are required. In this paper, the analytical results of the overall Signal to Interference and Noise Ratio (SINR) coverage probability and the rate coverage probability are derived under the stochastic geometric framework. The optimal region bias ranges for maximizing the rate coverage probability are also analysed. The results show that the ABSF still outperform the LPSF in terms of rate with the optimal range expansion bias, but lead to a heavier burden on the back-haul of the pico-cell. However, with a static range expansion bias, the LPSF provide better rate coverage than the ABSF. Also, in a low range expansion scenario, the reduced power of the LPSF has negligible effect on the rate coverage with the optimal resource partitioning.

No abstract

No abstract

Three-dimensional (3D) multi-input-multi-output (MIMO) is one of the enabling technologies for next-generation mobile communication. As the elevation angle in the 3D MIMO channel model might vary against the height of the base station (BS) antenna, it should be considered within channel modeling. In this paper, the impact of antenna height on the channel characteristics of the 3D MIMO channel is investigated by using the intelligent ray launching algorithm (IRLA). Three typical street scenarios, i.e., the straight street, the forked road, and the crossroad, are selected as benchmarks. The joint and marginal probability density functions (PDFs) of both the elevation angle of departure (EAoD) and the elevation angle of arrival (EAoA) are obtained through simulations. Moreover, the elevation angle spread (AS) and the elevation delay spread (DS) under various antenna heights are jointly discussed. Simulation results show that the characteristics of the PDFs of EAoD will vary under different street scenarios. It is observed that in order to obtain the maximum or minimum value of the AS and the DS, the BS antenna should be deployed at half of the building height.

No abstract

With data traffic explosion, operating Long-Term Evolution (LTE) in the 5 GHz unlicensed band, which has already been used by WiFi networks, has been proposed. To harmoniously coexist with the incumbent WiFi networks, LTE-Licensed Assisted Access (LAA) has been proposed recently, advocating cellular networks to access the unlicensed band by employing listen-before-talk mechanism. However, the performance of LAA has not been analysed under multiple accessible unlicensed channels (UCs). In this work, we analyse the user throughput and spatial spectral efficiency (SSE) of the multi-UC coexisting LTE-LAA and WiFi networks versus the network density based on the Matern hard core process. The throughput and SSE are obtained as functions of the downlink successful transmission probability (STP), of which analytical expressions are derived and validated by Monte Carlo simulations. The results show that an optimal LTE access point (LAP) density exists to maximise the LTE-LAA user equipment (LUE) throughput, and our derived closed-form STP lower bound of LUE can be used to obtain a sufficiently accurate prediction of the optimal LAP density. Moreover, the SSE does not change much under relatively low LAP densities, and when the LAP density is larger than 1, 585 LAPs per km 2 , the SSE approaches the asymptotic SSE as the LAP density approaches infinity. INDEX TERMS LTE-LAA, WiFi, multiple unlicensed channels, Matern hard core process, successful transmission probability.