The structures of large-scale software systems are complex and difficult to understand for designers and developers. Traditional software metrics can hardly describe the structural complexity in modern software, and finding a quantitative method to depict and analyze large-scale software is still a challenge. In this paper we use complex networks theory to study software structure; in particular, we visualize the software graph and use the k-core to study it based on a recursive pruning of the least connected vertices. Different types of software are analyzed and some new noticeable properties are found, such as similar coreness, the vital highest core, high-core connecting tendency, and evolution stability. These features suggest that software is organized in a defined hierarchy of increasing centrality from outside to inside. The k-core analysis can help developers to improve software understanding, instruction test, and measurement and evaluation of the system in development.
The present study was designed to determine the renoprotective and hepatoprotective effect of lidocaine in septic rats through the Toll‑like receptor 4 (TLR4) signaling pathway. Adult male Sprague‑Dawley rats were randomly divided into the following three groups: control, sepsis model and 10% lidocaine. A model of sepsis was established by injection of lipopolysaccharide (LPS; 5 mg/kg) into the intraperitoneal cavity of rats. The same volume of saline was injected intraperitoneally into rats of the control group instead of LPS. Light microscopy was used to observe structural changes of the hepatic and nephridial tissues. qPCR was used to measure TLR4 mRNA expression levels and the protein expression was detected by flow cytometry. Western blotting was used to measure myocardial nuclear factor κB (NF‑κB) protein levels and ELISA was used to measure the levels of interleukin‑6 (IL‑6) in hepatic and nephridial tissues. The results demonstrated that 10% lidocaine treatment markedly decreased hepatic and nephridial injury in septic rats and inhibited the expression levels of TLR4, NF‑κB and IL‑6, which were upregulated in the sepsis model. In addition, the results indicated that lidocaine protects against renal and hepatic dysfunction in septic rats, which may be mediated by the downregulation of TLR4 and associated signaling molecules and inhibition of the inflammatory response.
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