Polydopamine capsule has aroused
wide attention since its emergence,
because of its biocompatibility and the great potential as drug delivery
carrier. However, preparing the nanometer PDA capsule (PDAC) is still
remained a challenge, especially with the size below 300 nm. Moreover,
there is little research about its photoacoustic imaging (PAI) and
photothermal therapy (PTT) effect. In this paper, we reported an improved
DMDES emulsion template method to obtain 200 nm PDAC, and act as highly
efficient theranostic agent for photoacoustic imaging (PAI) and chemo-photothermal
synergistic therapy. Due to its hollow structure and the higher photothermal
conversion efficiency (η), the PDAC showed excellent PAI ability
as its PA intensity was far outweigh the PBS and over two folders
than the same size polydopamine particles (PDAP) at the same concentration
in vitro. The animal experiment also verified this conclusion. Then
the anticancer drug-doxorubicin (DOX) was loaded on PDAC via electrostatic
interaction and π–π stacking. Moreover, the drug
release was pH responsive and NIR laser responsive to minimize the
side effect, and this system was proved to efficiently ablate the
tumor in vitro and in vivo experiments. This research highlights the
great potential of PDA capsule as a new theranostic agent.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.