C3F8 tamponade combined with laser photocoagulation could be an alternative treatment for highly myopic foveoschisis.This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
BackgroundThe fertility of female kidney transplant recipients is increasing with the progression of transplant management. This article aims to evaluate the clinical prognosis of mothers and newborns for post-kidney transplant couples.MethodsFrom January 2019 to April 2022, a total of four couples, all kidney transplant recipients, were successfully prepared for pregnancy after a rigorous preconception evaluation, including three cases of natural conception and one case of in vitro fertilization. Data regarding the mother and newborn, including general clinical condition and laboratory results, were recorded and assessed throughout the pregnancy and up until 12 months after delivery.ResultsThe mean conception age of the mothers was 34.8 years (30–38 years), and the mean interval between renal transplantation and pregnancy was 6.6 years (3.7–8.7 years). All deliveries were by cesarean section and took place without incident. There were three premature births (<37 weeks; average 35.1 weeks). In case 1 (in vitro fertilization), pre-eclampsia occurred during maternity, and this was the only case in which the fetal weight was less than 2,500 g (average 2,576.7 g). The mean Apgar score (1 min) was 7.8 (6–9) and reached 9 in all cases at 5 min. The mothers’ eGFR rose during mid-gestation, decreased in late pregnancy, and was largely restored along with proteinuria 1 year postpartum. Postnatal evaluation at 6 months showed normal neurological development. In addition, NK cell and IFN-γ levels increased and Treg cell and IL-10 levels decreased along with the onset of pre-eclampsia.ConclusionsPregnancies can succeed in couples who are both kidney transplant recipients. However, there might be higher risks of infertility, prematurity, and low birth weight.
Purpose: Compare the thickness of the retinal ellipsoidal zone in patients with Reticular Macular Disease (RMD) to a control population.Methods: This case-control study was conducted on patients diagnosed with RMD at the First Affiliated Hospital of Guangzhou Medical University from April 2018 to November 2018. We identified 25 cases who were diagnosed with RMD and 20 normal control eyes. Divide the posterior pole into five regions (superior, inferior, nasal, temporal, and subfoveal zones), and manually measure the five regions posterior ellipsoidal zone thickness, all the images were obtained by SD-OCT. Generalized estimating equation models were used to control for potential confounders and within-subject variation.Results: The mean ellipsoidal zone thickness in RMD patients five regions were all significantly lower than in the control group (all P<0.01). The mean ellipsoidal zone thickness value in men with RMD has a more significant change than females. Furthermore, the mean ellipsoidal zone thickness of reticular pseudodrusen (RPD) eyes with drusen were not significantly different from the pure RPD eyes (P=0.34). Conclusions: Our findings reveal that the mechanism of RMD occurs may be related to damage to the mitochondria of photoreceptor cells, which may be one of the mechanisms that RMD occurs. When the impairment degree of mitochondria reach to a certain level, may lead to further vision loss in RMD patients. Therefore, to protect the retinal ellipsoidal zone and its mitochdrial early is important to prevent further impairment of visual function and vision loss.
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