Introduction:
Sebaceous carcinoma of the eyelid is the third most common eyelid malignancy, after basal cell carcinoma and squamous cell carcinoma. It is highly malignant and potentially aggressive. Surgical excision is currently the best treatment option for this condition. Patients often require reconstruction surgery to repair eyelid defects to achieve normal eyelid function and appearance. However, no comprehensive systematic review has assessed the efficacy and safety of eyelid defect reconstruction. This protocol was developed to conduct a systematic review and meta-analysis to evaluate evidence related to the efficacy and safety of reconstruction.
Methods:
We will systematically search the Cochrane Library, PubMed, Web of Science, China National Knowledge Infrastructure, WanFang Database, and Chinese Biomedical Literature Database from their inception to February 2023 for studies on eyelid defect reconstruction. We will identify other potential studies using multiple methods such as manual searching. The outcomes were eyelid function, eyelid morphology, patient satisfaction, recurrence rate, metastasis rate, tumor-related mortality, and adverse events. Two researchers will independently screen titles and abstracts, identify full-text studies for inclusion, extract data, and appraise the risk of bias in the included studies. A meta-analysis will be conducted using Review Manager 5.4 and R software. The certainty of evidence will be appraised by grading of recommendations, assessment, development, and evaluation system.
Results:
This full-text will adhere to the preferred reporting items for systematic reviews and meta-analyses statement to ensure clarity and completeness of reporting in all phases of the systematic review.
Discussion:
This study provides evidence of the efficacy and safety of reconstruction methods for sebaceous carcinoma of the eyelid.
The current study aimed to investigate the effect of input enhancement on L2 Chinese classifier learning. Two parallel groups of preliminary-level international participants and one group of Chinese native participants were recruited, and the three groups were matched in Chinese writing experience and group size (n = 28). One group of international participants was randomly selected as the experimental group; they read a classifier-enhanced text for 10 min before performing a writing task. The other international group and the native group served as the L2-learner control group and the L1-learner control group, respectively. These two control groups performed the writing task without text reading. Results showed that likely due to the frequent use of 个/ge4/ and the extensive use of novel classifiers, a greater variety of classifiers were used by the experimental group at a greater frequency as compared with the two control groups. However, given the observation that the experimental group tended to avoid using complex classifier forms and similar classifiers, future CSL instruction is suggested to aim for quality acquisition through long-term application of input enhancement integrated with explicit explanation on a language-use basis. This study furthers our understanding of how input enhancement is applicable to the acquisition of a logographic second language.
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