A mild
two-step synthetic approach for the preparation of structurally
valuable indolo[3′,2′:4,5]pyrrolo[3,2,1-kl]phenothiazines has been developed. In this work, cyclohexanone was
used as the key bridge to connect the indole and phenothiazine frameworks
to construct a structurally valuable indole-fused derivative. The
present protocol achieved the cascade construction of multiple C–hetero
bonds, affording a convenient approach access to hexacyclic-fused
system that contained both indole and phenothiazine, two privileged
skeletons.
A convenient
and efficient strategy for the synthesis of dibenzoxazepinamines
and dibenzothiazepinamines has been developed. This three-component
approach started from 2-nitrobenzaldehydes, 2-aminophenols, and methoxyammonium
chlorides under metal-free conditions. The protocol has the advantages
of readily available starting materials, simple and facile conditions,
gram-scale synthesis, and broad substrate scope, providing an efficient
and practical strategy for the preparation of potential drug-active
dibenzoxazepinamines and dibenzothiazepinamines in one pot.
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