Mild Alkaline Hydrolysis of Aconitine
SummaryHydrolysis of aconitine (1) with 0 . 0 4~ K,CO, in 90% MeOH at room temperature yields, besides the alkamine aconine 3 considerable amounts of 8-0 -methylaconine (6) and smaller quantities of desbenzoyl-pyroaconitine (4) and 16-epi-desbenzoyl-pyroaconitine (5). Better yields of 4 and 5 are obtained when heating a solution of aconitine in 0 . 0 4~ K,CO, in 90% EtOH. 7. Mitteilung iiber Aconitum. Mitteilung 6: [I]. Die Kristallisation von Benzoylaconin und die Beobachtung der Komplexitit der Hydrolyseprodukte wurde zuerst unter der Mitarbeit van Frl. Esther Stuehelin gemacht.
Aconitin (Ia) hydrolysiert unter den gegebenen Bedingungen unter Bildung von Aconin (Ib) (= Hauptprodukt) und den Derivaten (IIa) und (IIb), wobei der Anteil an (II) beim Kochen in K2CO3 ansteigt.
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