No abstract

No abstract

A mechanical balance between intraocular pressure and tissue stiffness defines the refractive shape of the human cornea. More and more daily surgical procedures modify that shape to achieve vision correction, which increases the demand for a profound understanding of the tissue mechanics. The wide variety of published mechanical properties foreshadows the difficulty of this task. The aim of this study is to show that such problems may arise from using the inverse method for fitting material models with multiple coefficients to a limited number (usually one) of experimental data. Using multiple sets of experimental data for the fitting process is proposed as a possible solution.

A method of quantitative evaluation of the number of microaneurysms is described for clinical research in the therapy of early stages of diabetic retinopathy. In a double-blind study it can be demonstrated that the described method quantifies the progression of retinopathy statistically during only one year of observation in 32 resp. 40 patients. The difficulties of quantification are due to interpretation problems of the photographic documentation and the learning problem of the observer.